Scutoids are a geometrical solution to three-dimensional packing of epithelia
Scutoids are a geometrical solution to three-dimensional packing of epithelia
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DOI：
10.1038/s41467-018-05376-1
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发表时间：
2018-07-27
影响因子：
16.6
通讯作者：
Escudero, Luis M.
中科院分区：
文献类型：
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作者：
Gomez-Galvez, Pedro;Vicente-Munuera, Pablo;Escudero, Luis M.
随着动物的发育，组织弯曲有助于将器官塑造成复杂的三维结构。然而，弯曲上皮的结构和堆积在很大程度上仍然未知。在这里，我们通过数学模型表明，弯曲上皮中的细胞可以沿着顶端基底轴进行插入。这种现象迫使细胞在其基部和顶端表面具有不同的邻居。结果，上皮细胞呈现出一种新的形状，我们称之为“scutoid”。对不同组织的详细分析证实，细胞之间顶端-基底嵌入的产生是形态发生过程中的一个共同特征。利用生物物理学的论证，我们提出盾片可以使组织能量最小化并稳定三维堆积。因此，我们得出结论，盾片是实现上皮弯曲的自然解决方案之一。我们的发现为理解上皮器官的三维组织铺平了道路。
As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.