Numerical investigation into the effects of ordered particle packing and slip flow on the performance of chromatography
Numerical investigation into the effects of ordered particle packing and slip flow on the performance of chromatography
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有序颗粒堆积和滑流对色谱性能影响的数值研究。
DOI：
10.1002/jssc.201201109
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发表时间：
2013-05-01
影响因子：
3.1
通讯作者：
Wang, Qiuwang
中科院分区：
文献类型：
--
作者：
Yan, Xiaohong;Wang, Qiuwang
采用体积平均法计算了面心立方、体心立方和简单立方三种颗粒填充层析柱的压降和板高。研究发现，Kozeny-Carman方程对面心立方结构的压降给出了合理的预测，但对体心立方和简单立方结构的压降估计过高。面心立方结构比体心立方结构、简单立方结构和随机结构的纵向色散系数更小。面心立方滑移流的压降和板高均低于无滑移流。无滑移流动和滑移流动时，面心立方结构颗粒填充柱的最小减板高度分别约为0.084和0.059。有序颗粒堆积结构的板高较小，滑移流对板高的影响不如文献报道的显著。
The pressure drop and the plate height of chromatography columns packed with particles in the face-centered cubic, the body-centered cubic and the simple cubic configurations are calculated by a volume averaging method model. It is found that the Kozeny-Carman equation provides a reasonable prediction of the pressure drop when particles are in the face-centered cubic configuration, but overestimates the pressure drop when particles are in the body-centered cubic and the simple cubic configurations. The face-centered cubic configuration has the advantage to provide a smaller longitudinal dispersion coefficient than the body-centered cubic, the simple cubic, and the random configurations. The pressure drop and the plate height for slip flow through particles in the face-centered cubic configuration are lower than that for no-slip flow. The values of the smallest reduced plate height of columns packed with particles in the face-centered cubic configuration for no-slip flow and slip flow are about 0.084 and 0.059, respectively. The plate height of the ordered particle packing structures is smaller and the effect of slip flow on the plate height is less remarkable than results reported in literature.