Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect
Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect
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DOI：
10.1016/j.fct.2013.07.029
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发表时间：
2013-10-01
影响因子：
4.3
通讯作者：
Yen, Feng-Lin
中科院分区：
文献类型：
--
作者：
Lee, Chiang-Wen;Ko, Horng-Huey;Yen, Feng-Lin
Artocarpin是从农业植物Artocarpus Commis中分离得到的一种戊烯基黄酮类化合物，已被证明具有抗炎和抗癌活性。由于氧化应激和炎症促进了中波紫外线(UVB)辐射诱导的光损伤的发展，本研究旨在评价青蒿素对UVB诱导的无毛小鼠皮肤损伤的光保护作用。外用0.05%和0.1%的青蒿素通过减少皮肤脱屑、表皮增厚和晒伤细胞形成等组织病理学改变而显示出明显的光保护作用，但0.1%的青蒿素没有表现出更好的效果。在抗氧化活性方面，青蒿素具有显著的抗氧化性(P<；0.05)，可降低体内活性氧和脂质过氧化水平。此外，青蒿素还能显著降低肿瘤坏死因子-α和白介素1-β水平，从而下调炎症蛋白，包括胞浆磷脂酶A2和环氧合酶-2的合成(P<；0.05)。综上所述，这些数据表明青蒿素可以预防UVB辐射引起的无毛小鼠皮肤损伤，这可能是通过其抗氧化和抗炎机制来实现的。因此，我们认为Artocarpin在医药和/或化妆品中可能是一种有用的光保护剂。(C)2013爱思唯尔有限公司。保留所有权利。
Artocarpin, a prenylated flavonoid isolated from an agricultural plant Artocarpus communis, has been documented to possess anti-inflammation and anticancer activities. As oxidative stress and inflammation promote the development of ultraviolet B (UVB) irradiation-induced photodamage, the aim of the present study was to evaluate the photoprotective effect of artocarpin on UVB-induced skin damage in hairless mice. Artocarpin at a topical dose of 0.05% and 0.1% showed a significant photoprotective effect by decreasing histopathological changes, such as desquamation, epidermal thicken and sunburn cell formation, but 0.1% of artocarpin administration did not show better effect. Regarding the antioxidant activities, artocarpin exhibited a significant effect (P < 0.05) by decreasing levels of reactive species oxygen and lipid peroxidation. In addition, artocarpin can significantdecrease the level of tumor necrosis factor-alpha and interleukin-1 beta for downregulating the inflammation protein, including the synthesis of cytosolic phospholipase A2 and cyclooxygenase-2 (P < 0.05). In conclusion, these data suggest that artocarpin can prevent skin damage from UVB irradiation-induced photodamage in hairless mice and this is likely mediated through its antioxidant and anti-inflammation mechanisms. Therefore, we suggested that artocarpin could be a useful photoprotective agent in medicine and/or cosmetics. (C) 2013 Elsevier Ltd. All rights reserved.