Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.
Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci.
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junB 的复杂遗传组织：小鼠和人类 junB 位点的多个侧翼进化保守序列块。
DOI：
10.1006/geno.1995.1135
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Ryder,K
中科院分区：
文献类型：
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作者：
Phinney,DG;Tseng,SW;Ryder,K
对小鼠和人类JunB基因座的比较显示，DNA远端5‘和3’侧翼的九个区域显示出72%以上的序列一致性。这些侧翼进化保守序列(FEC)中包含很大一部分JunB基因座(超过50%)，这可能是影响该基因适当转录调控所必需的。只对一小部分脊椎动物基因进行了涉及远端侧翼DNA千碱基的比较序列分析。现有的数据和结果表明，FEC可能成为基因的常见但重要的功能成分，这一假说对表征与人类疾病有关的基因具有重要意义。
A comparison of the murine and human junB loci reveals nine regions of distal 5′- and 3′-flanking DNA that exhibit greater than 72% sequence identity. A large fraction (over 50%) of the junB locus is contained in these flanking evolutionarily conserved sequences (FECS), which may be required for effecting the proper transcriptional regulation of this gene. Comparative sequence analyses involving kilobases of distal flanking DNAs have been performed for only a small number of vertebrate genes. The available data and the results presented here suggest that FECS may emerge as common yet important functional components of genes, a hypothesis with significant implications for characterizing genes involved in human disease.