Isoflurane and ketamine anesthesia have different effects on ventilatory pattern variability in rats
Isoflurane and ketamine anesthesia have different effects on ventilatory pattern variability in rats
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DOI：
10.1016/j.resp.2012.12.001
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发表时间：
2013-02-01
影响因子：
2.3
通讯作者：
Jacono, Frank J.
中科院分区：
文献类型：
--
作者：
Chung, Augustine;Fishman, Mikkel;Jacono, Frank J.
我们假设异氟烷和氯胺酮对呼吸模式变异性（VPV）的影响不同。在深度麻醉之前、期间和之后，在全身体积描记器中记录成年Sprague-Dawley大鼠。VPV量化从60年代的时代，使用一套互补的分析技术，包括构建替代数据集，保留线性结构，但破坏非线性确定性的原始数据。尽管异氟烷降低，氯胺酮增加呼吸频率，但两种麻醉剂的VPV（通过变异系数定量）均降低。此外，互信息增加和样本熵降低和非线性复杂性指数（NLCI）增加麻醉期间，尽管波形的形状和周期的定性差异。令人惊讶的是，互信息和样本熵在异氟烷数据构建的替代集中没有变化，但在氯胺酮数据构建的替代集中，互信息增加，样本熵显着降低，从麻醉相对于未麻醉时期构建的替代段。这些数据表明，不同的机制调节呼吸的线性和非线性变化。由爱思唯尔公司出版
We hypothesize that isoflurane and ketamine impact ventilatory pattern variability (VPV) differently. Adult Sprague-Dawley rats were recorded in a whole-body plethysmograph before, during and after deep anesthesia. VPV was quantified from 60-s epochs using a complementary set of analytic techniques that included constructing surrogate data sets that preserved the linear structure but disrupted nonlinear deterministic properties of the original data. Even though isoflurane decreased and ketamine increased respiratory rate, VPV as quantified by the coefficient of variation decreased for both anesthetics. Further, mutual information increased and sample entropy decreased and the nonlinear complexity index (NLCI) increased during anesthesia despite qualitative differences in the shape and period of the waveform. Surprisingly mutual information and sample entropy did not change in the surrogate sets constructed from isoflurane data, but in those constructed from ketamine data, mutual information increased and sample entropy decreased significantly in the surrogate segments constructed from anesthetized relative to unanesthetized epochs. These data suggest that separate mechanisms modulate linear and nonlinear variability of breathing. Published by Elsevier B.V.