CORTICAL DOPAMINERGIC INVOLVEMENT IN COCAINE REINFORCEMENT
CORTICAL DOPAMINERGIC INVOLVEMENT IN COCAINE REINFORCEMENT
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DOI：
10.1126/science.6879176
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
SMITH, JE
中科院分区：
文献类型：
--
作者：
GOEDERS, NE;SMITH, JE
参与可卡因强化启动的神经元系统进行了研究，确定直接应用药物的大脑部位正在加强。这是通过让大鼠将皮摩尔浓度的可卡因自我施用到离散的大脑区域来实现的。内侧前额叶皮层支持自我管理，而背侧核和腹侧被盖区没有。通过在微量注射系统中加入等摩尔浓度的多巴胺能D2受体拮抗剂舒必利来减弱自我给药。显然，可卡因强化部分是通过对中皮层多巴胺能受体的直接作用介导的。
Neuronal systems involved in the initiation of cocaine reinforcement were investigated by identifying brain sites where direct application of the drug was reinforcing. This was accomplished by allowing rats to self-administer picomolar concentrations of cocaine into discrete brain regions. The medial prefrontal cortex supported self-administration, while the nucleus accumbens and ventral tegmental area did not. Self-adminstration was attenuated by including equimolar concentrations of the dopaminergic D2-receptor antagonist sulpiride in the microinjection system. Apparently, cocaine reinforcement is mediated in part through a direct action on mesocortical dopaminergic receptors.