Forty‐five-month follow‐up of extracranial carotid arterial disease for new coronary events in elderly patients
Forty‐five-month follow‐up of extracranial carotid arterial disease for new coronary events in elderly patients
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老年患者颅外颈动脉疾病新冠事件45个月随访
DOI：
10.1097/00019501-199203000-00012
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发表时间：
1992
影响因子：
1.8
通讯作者：
M. Schoenfeld
中科院分区：
文献类型：
--
作者：
W. Aronow;M. Schoenfeld
一项前瞻性研究评估了949例平均年龄为82 ± 8岁的患者的颈动脉双功超声检查发现的40%至100%颅外颈动脉疾病（ECD）的患病率及其与冠状动脉疾病（CAD）和新发冠状动脉事件发生率的关系。方法在慢性病护理机构中对949名未选择的患者（平均年龄82 ± 8岁）进行了技术充分的双侧颈动脉双功超声检查。冠心病的患病率和冠状动脉事件的发生率在有和没有ECD的患者中进行了测定。随访45 ± 22个月。数据采用卡方分析。结果150例ECD患者中87例（58%）有CAD，799例无ECD患者中314例（39%）有CAD（P < 0.001）。87例ECD合并CAD患者中有70例（80%）（A组）、314例CAD无ECD患者中有188例（60%）（B组）、63例ECD无CAD患者中有28例（44%）（C组）和485例无ECD无CAD患者中有133例（27%）（D组）发生冠状动脉事件。A与B、A与C、A与D以及B与D相比，P值显著性为P < 0.001; C与D相比，P值显著性为P < 0.01; B与C相比，P值显著性为P < 0.025。结论ECD患者冠心病患病率和冠状动脉事件发生率均高于非ECD患者。冠心病合并心内膜异位症患者的冠状动脉事件发生率高于冠心病合并心内膜异位症患者。有ECD且无CAD的患者冠状动脉事件的发生率高于无ECD且无CAD的患者。
BackgroundA prospective study evaluated the prevalence of 40% to 100% extracranial carotid arterial disease (ECD) by carotid duplex ultrasonograms and its association with coronary artery disease (CAD) and incidence of new coronary events in 949 patients with a mean age of 82 ± 8 years. MethodsTechnically adequate bilateral carotid duplex ultrasonograms were obtained in 949 unselected patients, mean age 82 ± 8 years, in a chronic care facility. The prevalence of CAD and incidence of coronary events were determined in patients with and without ECD. Follow-up was 45 ± 22 months. Data were analyzed by chi-square analyses. ResultsCAD was present in 87 of 150 patients (58%) with ECD and in 314 of 799 patients (39%) without ECD (P < 0.001). Coronary events occurred in 70 of 87 patients (80%) with ECD and CAD (group A), in 188 of 314 patients (60%) with CAD and no ECD (group B), in 28 of 63 patients (44%) with ECD and no CAD (group C), and in 133 of 485 patients (27%) with no ECD and no CAD (group D). Significant P values were P < 0.001 comparing A with B, A with C, A with D, and B with D; P < 0.01 comparing C with D; and P < 0.025 comparing B with C. ConclusionsPatients with ECD have a higher prevalence of CAD and a higher incidence of coronary events than patients without ECD. Patients with CAD and ECD have a higher incidence of coronary events than patients with CAD and no ECD. Patients with ECD and no CAD have a higher incidence of coronary events than patients with no ECD and no CAD.