CCR4 Expression by Atypical T Cells in Systemic Pilotropic Lymphoma: Its Behavior under Treatment with Interferon Gamma, Topical PUVA and Systemic Retinoid
CCR4 Expression by Atypical T Cells in Systemic Pilotropic Lymphoma: Its Behavior under Treatment with Interferon Gamma, Topical PUVA and Systemic Retinoid
复制标题
系统性先导性淋巴瘤中非典型 T 细胞的 CCR4 表达：其在干扰素 γ、局部 PUVA 和系统性视黄醇治疗下的行为
作者：
T. Fujimura;S. Aiba;Y. Yoshino;S. Kuroki;Y. Kimura;K. Kikuchi;T. Kunii;J. Matsunaga;K. Matsushima;H. Tagami
我们描述了一个88岁的日本患者与试点T细胞淋巴瘤涉及外周血和淋巴结。该患者表现为多发红色滤泡丘疹，汇合性浸润性红斑斑块和结节。此外，他还因为头皮和眉毛的全秃而引人注目。组织病理学上，病变皮肤显示密集的滤泡和滤泡周围浸润非典型淋巴细胞。流式细胞术显示存在弱CD4+ CCR4+细胞群，这在健康对照的外周血中是检测不到的。患者对局部PUVA和全身依维甲酸（类维甲酸-PUVA）和静脉注射IFN-γ反应良好。与外周血中非典型细胞的减少平行，弱CD4+ CCR4+ T细胞的百分比下降。然而，在我们因副作用停止治疗约1周后，淋巴结肿大变得突出，4周后，患者在重新开始任何特定化疗之前死亡。
We describe an 88-year-old Japanese patient with pilotropic T cell lymphoma involving the peripheral blood as well as lymph nodes. This patient presented with multiple red follicular papules, confluent, infiltrated erythematous plaques and nodules. Moreover, he was conspicuous for the presence of total alopecia of the scalp and eyebrows. Histopathologically, the lesional skin showed dense follicular and perifollicular infiltrates of atypical lymphocytes. The flow cytometry disclosed the presence of weakly CD4+ CCR4+ cell populations that would not be detected in the peripheral blood from healthy controls. The patient responded well to topical PUVA and systemic etretinate (retinoid-PUVA) and intravenous IFN-γ. Parallel with the decrease in atypical cells in the peripheral blood, the percentage of weakly CD4+ CCR4+ T cells declined. However, about 1 week after we discontinued this treatment because of the side effects, the lymph node swelling became prominent, and, 4 weeks later, the patient died before restarting any specific chemotherapy.
联合免疫调节疗法治疗皮肤 T 细胞淋巴瘤：单个机构 14 年的经验。
影响因子：
--
作者：
Suchin,KarenRebecca;Cucchiara,AndrewJ;Gottleib,ScottL;Wolfe,JonathanT;DeNardo,BarbaraJ;Macey,WilliamH;Bromley,PatriciaG;Vittorio,CarmelaC;Rook,AlainH
通讯作者：
Rook,AlainH
影响因子：
6.5
作者：
VOWELS, BR;LESSIN, SR;ROOK, AH
通讯作者：
ROOK, AH