Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat
Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat
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DOI：
10.1002/nau.22297
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发表时间：
2013-04-01
影响因子：
2
通讯作者：
Satoh, Keisuke
中科院分区：
文献类型：
--
作者：
Saito, Motoaki;Shimizu, Shogo;Satoh, Keisuke
目的越来越多的证据表明，1受体阻滞剂可以预防人类良性前列腺增生相关的膀胱过动症和夜尿症，我们在自发性高血压大鼠（SHR）模型中研究西洛多辛和纳托地尔对高血压相关膀胱功能障碍的影响。材料与方法12周龄雄性SHRs不给予西洛多辛（100 μ g/kg, p.o）或萘托地尔（10或30mg/kg， p.o）治疗，每日1次，连续6周。以Wistar大鼠为正常血压对照。治疗6周后，通过代谢笼（分别为暗周期和光周期）和膀胱计量学研究估计排尿功能。此外，采用氢清除法测量膀胱血流量（BBF）。结果与Wistar组相比，代谢笼和膀胱造影显示SHRs的排尿频率显著增加，血脑密度和单次排尿量均显著减少。西洛多辛治疗使下降的血脑密度正常化，而纳托地尔治疗以剂量依赖的方式增加了SHR组的血脑密度。尽管西洛多辛和高剂量纳托地尔治疗可显著抑制1天内的排尿频率，但与未治疗的SHRs相比，只有高剂量纳托地尔治疗可显著抑制光周期内的排尿频率和尿量。虽然西洛多辛和高剂量纳托地尔治疗显著增加单次排尿量，但仅西洛多辛治疗可显著抑制膀胱造影显示的非排尿性收缩。结论西洛多辛和纳洛多辛均可改善SHR中高血压相关性膀胱功能障碍，而纳托地尔而非西洛多辛可通过抑制尿生成而改善光周期尿频。Neurourol。生物力学学报。32:393398,2013。(c) 2012 Wiley期刊有限公司
Purpose As increasing evidence suggest that 1-blockers prevent benign prostatic hyperplasia related overactive bladder and nocturia in the human, we investigated the effects of silodosin and naftopidil on hypertension-related bladder dysfunction in the spontaneously hypertensive rat (SHR) model. Materials and Methods Twelve-week-old male SHRs received no treatment or treatment with silodosin (100 mu g/kg, p.o.) or naftopidil (10 or 30mg/kg, p.o.) once daily for 6 weeks. Wistar rats were used as normotensive controls. After 6-week treatment, voiding functions were estimated by metabolic cages (dark- and light-cycle separately) and cystometric studies. Furthermore, the bladder blood flow (BBF) was measured employing the hydrogen clearance method. Results SHRs showed significant increases in micturition frequency, and decreases in BBF and single voided volume in both metabolic cages and cystometrograms compared to the Wistar group. Treatment with silodosin normalized the decreased BBF, and treatment with naftopidil increased the BBF in a dose-dependent manner in the SHR group. Although treatment with silodosin and the high dose of naftopidil significantly inhibited micturition frequency in one day, only treatment with the high dose of naftopidil significantly inhibited micturition frequency and urine production in the light-cycle compared to the non-treated SHRs. Although treatment with silodosin and the high dose of naftopidil significantly increased single voided volume, only treatment with silodosin significantly inhibited non-voiding contractions in the cystometrgrams. Conclusion Our data suggest that both silodosin and naftopidil improve hypertension-related bladder dysfunction in the SHR, and naftopidil but not silodosin improves urinary frequency in the light-cycle due to inhibition of urine production. Neurourol. Urodynam. 32: 393398, 2013. (c) 2012 Wiley Periodicals, Inc.