Materno-fetal transmission of human coronaviruses: a prospective pilot study
Materno-fetal transmission of human coronaviruses: a prospective pilot study
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DOI：
10.1007/s10096-008-0505-7
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发表时间：
2008-09-01
影响因子：
4.5
通讯作者：
Payan, C.
中科院分区：
文献类型：
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作者：
Gagneur, A.;Dirson, E.;Payan, C.
这项前瞻性初步研究调查了导致新生儿感染病例的人类冠状病毒（HCoV）母婴传播的可能性。通过真实的时间RT PCR检测159份来自母婴夫妇的样本，研究了这种垂直传播：分娩期间的母亲阴道（MV）和呼吸道（MR）样本;以及新生儿胃样本（NG），并检测HCoV（229 E，OC-43，NL-63，HKU 1）。HCoV在12个样本中检测到（229 E：11; HKU 1：1）从7个母亲-儿童夫妇。对于三对夫妇，只有MR检测呈阳性（病例1-3）。对于另外两对夫妇，所有三个样本（MV、MR和NG）均检测为阳性（病例4和5）。对于病例6，仅MV和NG检测为阳性。例7仅MV阳性。在这项初步研究中假设HCoV可能存在垂直传播，需要在更大范围内进行进一步调查。
This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1-3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.