Calgranulin B and KL-6 in Bronchoalveolar Lavage of Patients with IPF and NSIP
Calgranulin B and KL-6 in Bronchoalveolar Lavage of Patients with IPF and NSIP
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DOI：
10.1007/s10753-018-00955-2
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发表时间：
2019-04-01
期刊：
影响因子：
5.1
通讯作者：
Rottoli, Paola
中科院分区：
文献类型：
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作者：
Bennett, David;Salvini, Martina;Rottoli, Paola
特发性肺纤维化（IPF）和非特异性间质性肺炎（NSIP）是最常见的特发性间质性肺炎。本研究的目的是评估IPF和具有纤维化模式的特发性NSIP（i-NSIP）患者支气管肺泡灌洗液（BAL）中钙颗粒蛋白B和Krebs von den Lungen 6（KL-6）的浓度。30例IPF患者（68.73 +/-8.63岁）、30例i-NSIP患者（68.33 +/-7.45岁）和健康对照者入选本研究。IPF和i-NSIP患者BALF中钙颗粒蛋白B和KL-6均显著高于健康对照组（p75百分位数），且病情进展更严重，FEV1%、FVC%、RV%、TLC%、DLCO%、6 MWT步行距离和BALF中性粒细胞百分比较低。BAL中钙颗粒蛋白B和KL-6被证明是IPF和i-NSIP的可靠生物标志物，并具有预后意义，可区分重度和晚期患者。两种生物标志物的组合可以促进严重程度的分层。
Idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) are the most frequent idiopathic interstitial pneumonias. The aim of this study was to evaluate concentrations of calgranulin B and Krebs von den Lungen 6 (KL-6) in bronchoalveolar lavage (BAL) fluid of patients with IPF and idiopathic NSIP (i-NSIP) with fibrotic pattern. Thirty patients with IPF (68.73 +/- 8.63years), 30 with i-NSIP (68.33 +/- 7.45years), and healthy controls were included in the study. Calgranulin B and KL-6 both proved to be significantly higher in BAL of IPF and i-NSIP patients than in healthy controls (p75th percentile) had more advanced disease with lower values of FEV1%, FVC%, RV%, TLC%, DLCO% of predicted, distance walked in 6MWT, and BAL neutrophil percentage. Calgranulin B and KL-6 in BAL proved to be reliable biomarkers of IPF and i-NSIP and to have prognostic meaning, discriminating severe and advanced patients. The combination of the two biomarkers can facilitate the stratification of severity.