AN ENDOGENOUS OUABAIN-LIKE FACTOR ASSOCIATED WITH HYPERTENSIVE PREGNANT-WOMEN
AN ENDOGENOUS OUABAIN-LIKE FACTOR ASSOCIATED WITH HYPERTENSIVE PREGNANT-WOMEN
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DOI：
10.1210/jcem-59-6-1070
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发表时间：
1984-01-01
影响因子：
5.8
通讯作者：
WILLIAMS, GH
中科院分区：
文献类型：
--
作者：
GRAVES, SW;WILLIAMS, GH
通过地高辛RIA [放射免疫测定法]交叉反应性和哇巴因敏感性[Na，K] ATP酶的抑制作用，测定了49例未指化的晚期妊娠妇女羊水中哇巴因样因子（OLF）的水平。两种方法测得的硫酸盐含量具有显著相关性（P < 0.05）。在这项研究中，25名妇女的血压被认为是正常的，而24名妇女在目前的怀孕期间血压升高。当比较正常血压孕妇和高血压孕妇羊水中OLF的水平时，两种测定均显示高血压组中OLF的水平显著较高（P < 0.002）。此外，这些妇女在羊水穿刺时的舒张压与通过任一测定法测定的羊水OLF水平之间存在显著相关性（P < 0.002）。OLF显然在妊娠高血压并发症中起作用。
Levels of ouabain-like factor (OLF) were measured in amniotic fluid from 49 undigitalized 3rd trimester pregnant women by means of its cross-reactivity in a digoxin RIA [radioimmunoassay] and its inhibition of ouabain-sensitive [Na,K]ATPase. The sulfate from these 2 assays were significantly correlated (P < 0.05). Of the women included in this study, 25 had blood pressures considered normal for their gestational age, while 24 had developed during their current pregnancy blood presures judged to be elevated. When levels of OLF in the amniotic fluids from the normotensive and hypertensive pregnant women were compared, significantly higher levels were present in the hypertensive group for both assays (P < 0.002). Further, there was a significant correlation between the diastolic blood pressure of these women at the time of amniocentesis and the amniotic fluid OLF levels determined by either assay (P < 0.002). OLF apparently has a role in hypertensive complications of pregnancy.