Biological and experimental consequences of the zonal composition of solid tumors.
Biological and experimental consequences of the zonal composition of solid tumors.
复制标题
实体瘤区域组成的生物学和实验后果。
作者：
I. Fidler;I. Hart
K-1735黑色素瘤是一种可移植的鼠肿瘤，当其皮下生长时，由黑色素区和无色素区组成。肿瘤碎片的套管针移植研究的结果表明，这种表型多样性的表达可以在非常少的传代内终止。在平行实验中，来自整个肿瘤的细胞悬液的传代维持了黑色素产生的这种异质性。这些研究结果的影响进行了讨论。
The K-1735 melanoma is a transplantable murine tumor which, when growing s.c., is composed of melanotic and amelanotic areas. Results from trocar transplantation studies of tumor fragments show that expression of this phenotypic diversity can be terminated within very few passages. In parallel experiments, passage of cell suspensions derived from the whole tumor maintains this heterogeneity of melanin production. The implications of these findings are discussed.