EPIDEMIOLOGICAL EVIDENCE FOR CAUSAL RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS AND BURKITTS-LYMPHOMA FROM UGANDAN PROSPECTIVE-STUDY
EPIDEMIOLOGICAL EVIDENCE FOR CAUSAL RELATIONSHIP BETWEEN EPSTEIN-BARR VIRUS AND BURKITTS-LYMPHOMA FROM UGANDAN PROSPECTIVE-STUDY
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DOI：
10.1038/274756a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
HENLE, W
中科院分区：
文献类型：
--
作者：
DETHE, G;GESER, A;HENLE, W
1971年在乌干达开展的一项前瞻性血清流行病学研究结果表明，对eb病毒结构抗原具有高抗体滴度的儿童患伯基特淋巴瘤的风险很高。这些发现有力地支持了爱泼斯坦-巴尔病毒和伯基特淋巴瘤之间的因果关系，但表明该病毒的致癌潜力仅在特殊情况下才会实现。
Results from a prospective sero-epidemiological study initiated in Uganda in 1971 indicate that children with high antibody titers to Epstein-Barr virus structural antigens are at high risk of developing Burkitt''s lymphoma. These findings strongly support a causal relationship between the Epstein-Barr virus and Burkitt''s lymphoma, but suggest that the oncogenic potential of the virus is realized only in exceptional circumstances.