Electrochemical sensors for the detection of lead and other toxic heavy metals: the next generation of personal exposure biomonitors.
Electrochemical sensors for the detection of lead and other toxic heavy metals: the next generation of personal exposure biomonitors.
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DOI：
10.1289/ehp.10190
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发表时间：
2007-12
影响因子：
10.4
通讯作者：
Timchalk C
中科院分区：
文献类型：
--
作者：
Yantasee W;Lin Y;Hongsirikarn K;Fryxell GE;Addleman R;Timchalk C
为了支持生物监测计划的发展和实施，我们需要测量外源性暴露的定量技术。正在开发和验证基于微分析的传感器，这些传感器与血液、尿液或唾液等复杂的生物基质一起工作，将提高我们在化学暴露与疾病之间建立明确联系的能力。在有毒金属中，铅仍然是最有问题的金属之一。尽管在确定和消除铅暴露源方面做出了相当大的努力，但这种金属仍然是一个重大的健康问题，特别是对幼儿来说。正在进行的研究重点是开发便携式金属分析仪，这些分析仪与现有技术相比具有许多优势，因此可能代表下一代有毒金属分析仪。在这篇文章中，我们强调了两类金属分析仪的发展和验证的伏安法检测铅，包括：a）基于流动注射分析和阳极溶出伏安法在汞膜电极的分析仪，和B）汞无金属分析仪采用吸附溶出伏安法和新的纳米结构材料，包括自组装单分子膜上的介孔载体和碳纳米管。这些传感器已经过优化，可以像最先进的电感耦合等离子体质谱法一样准确地检测尿液、血液和唾液中的铅，具有高重现性和灵敏度。这些改进的便携式分析传感器平台将促进我们进行生物监测计划的能力，以了解化学品暴露评估和疾病结果之间的关系。
To support the development and implementation of biological monitoring programs, we need quantitative technologies for measuring xenobiotic exposure. Microanalytical based sensors that work with complex biomatrices such as blood, urine, or saliva are being developed and validated and will improve our ability to make definitive associations between chemical exposures and disease. Among toxic metals, lead continues to be one of the most problematic. Despite considerable efforts to identify and eliminate Pb exposure sources, this metal remains a significant health concern, particularly for young children. Ongoing research focuses on the development of portable metal analyzers that have many advantages over current available technologies, thus potentially representing the next generation of toxic metal analyzers. In this article, we highlight the development and validation of two classes of metal analyzers for the voltammetric detection of Pb, including: a) an analyzer based on flow injection analysis and anodic stripping voltammetry at a mercury-film electrode, and b) Hg-free metal analyzers employing adsorptive stripping voltammetry and novel nanostructure materials that include the self-assembled monolayers on mesoporous supports and carbon nanotubes. These sensors have been optimized to detect Pb in urine, blood, and saliva as accurately as the state-of-the-art inductively coupled plasma-mass spectrometry with high reproducibility, and sensitivity allows. These improved and portable analytical sensor platforms will facilitate our ability to conduct biological monitoring programs to understand the relationship between chemical exposure assessment and disease outcomes.
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影响因子：
10.4
作者：
Barbosa F Jr;Tanus-Santos JE;Gerlach RF;Parsons PJ
通讯作者：
Parsons PJ
影响因子：
4.9
作者：
Birnbaum, JC;Busche, B;Fryxell, GE
通讯作者：
Fryxell, GE
影响因子：
12.6
作者：
GAYET, JC;HAOUZ, A;BURSTEIN, C
通讯作者：
BURSTEIN, C
影响因子：
6.2
作者：
Honeychurch, KC;Hart, JP;Cowell, DC
通讯作者：
Cowell, DC
影响因子：
8.4
作者：
Desmond, D;Lane, B;Glennon, JD
通讯作者：
Glennon, JD