Subthalamic nucleus deep brain stimulation restores normal rapid eye movement sleep in Parkinson's disease.
Subthalamic nucleus deep brain stimulation restores normal rapid eye movement sleep in Parkinson's disease.
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丘脑底核深部脑刺激可恢复帕金森病患者正常的快速动眼睡眠。
DOI：
10.1002/mds.23862
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Toda H.
中科院分区：
文献类型：
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作者：
Nishida N;Murakami T;Kadoh K;Tohge R;Yamanegi M;Saiki H;Ueda K;Matsumoto S;Ishikawa M;Takahashi JA;Toda H.
研究背景帕金森病患者的睡眠障碍是一种常见的疾病年龄57.5 ± 9.8岁;疾病持续时间，12.3 ± 2.7岁）采用帕金森病睡眠量表和多导睡眠描记仪对患者进行丘脑底核脑深部电刺激治疗前后的睡眠状况进行比较丘脑底核脑深部电刺激这项研究的新发现显着增加了正常的快速眼动睡眠，并减少了帕金森病患者脑深部电刺激后无张力的异常快速眼动睡眠。改善的总睡眠量表评分与入睡后觉醒减少相关。此外，改善白天嗜睡与增加正常快速眼动睡眠时间相关。睡眠改善与运动并发症的解决或减少多巴胺能dosage.ConclusionsSubthalamic核脑深部电刺激可能对睡眠障碍在晚期帕金森氏病通过恢复睡眠结构和正常的快速眼动睡眠有有益的影响。© 2011运动障碍协会
BackgroundIn Parkinson's disease, sleep disturbance is a common occurrence.MethodsWe evaluated sleep in 10 patients with Parkinson's disease (age, 57.5 ± 9.8 years; disease duration, 12.3 ± 2.7 years) before and after subthalamic nucleus deep brain stimulation using the Parkinson's disease sleep scale and polysomnography.ResultsTheir total sleep scale scores and daytime sleepiness subscale scores significantly improved after subthalamic nucleus‐deep brain stimulation. The novel findings from this study significantly increased normal rapid eye movement sleep, and decreased abnormal rapid eye movement sleep without atonia after deep brain stimulation in patients with Parkinson's disease. The improved total sleep scale score correlated with decreased wakefulness after sleep onset. Moreover, improved daytime sleepiness correlated with increased normal rapid eye movement sleep time. Sleep improvement did not significantly correlate with resolution of motor complication or reduced dopaminergic dosages.ConclusionsSubthalamic nucleus‐deep brain stimulation may have beneficial effects on sleep disturbance in advanced Parkinson's disease by restoring sleep architecture and normal rapid eye movement sleep. © 2011 Movement Disorder Society