PROSITE: a documented database using patterns and profiles as motif descriptors.
PROSITE: a documented database using patterns and profiles as motif descriptors.
复制标题
DOI：
10.1093/bib/3.3.265
复制
发表时间：
2002-09-01
影响因子：
9.5
通讯作者：
Bucher, Philipp
中科院分区：
文献类型：
--
作者：
Sigrist, Christian J A;Cerutti, Lorenzo;Bucher, Philipp
在致力于识别蛋白质家族和结构域的各种数据库中，PROSITE 是第一个创建的数据库，此后一直在不断发展。 PROSITE 目前由大量具有生物学意义的基序组成，这些基序被描述为模式或概况，并链接到简要描述它们旨在检测的蛋白质家族或结构域的文档。 PROSITE 与 SWISS-PROT 蛋白质数据库的密切关系允许评估 PROSITE 基序的敏感性和特异性及其定期审查。作为回报，PROSITE 用于帮助注释 SWISS-PROT 条目。本文综述了PROSITE的主要特点以及所使用的家族和域名识别技术。
Among the various databases dedicated to the identification of protein families and domains, PROSITE is the first one created and has continuously evolved since. PROSITE currently consists of a large collection of biologically meaningful motifs that are described as patterns or profiles, and linked to documentation briefly describing the protein family or domain they are designed to detect. The close relationship of PROSITE with the SWISS-PROT protein database allows the evaluation of the sensitivity and specificity of the PROSITE motifs and their periodic reviewing. In return, PROSITE is used to help annotate SWISS-PROT entries. The main characteristics and the techniques of family and domain identification used by PROSITE are reviewed in this paper.