Mucociliary clearance following segmental tracheal reversal
Mucociliary clearance following segmental tracheal reversal
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DOI：
10.1097/00005537-199604000-00011
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发表时间：
1996-04-01
期刊：
影响因子：
2.6
通讯作者：
Feenstra, L
中科院分区：
文献类型：
--
作者：
DeLaere, PR;Liu, ZY;Feenstra, L
纤毛气管上皮细胞排列在一个极化模式，根据上呼吸道轴的气管，并负责运输粘液向喉。本实验在兔颈内翻气管上研究了纤毛运动方向及外界因素对纤毛清除方向的影响。16周后，通过观察放置在纤毛上皮倒置段和正常部分的硅胶颗粒的移动来研究气道清除率。纤毛在倒置的气管段内呈单向协调运动。如通过纤毛跳动产生的有效流动方向和扫描电子显微镜所示，倒置段中的纤毛与气管其余部分中的纤毛以相反的方向跳动。本研究表明，纤毛定向是不可逆的，但颈部气管内纤毛搏动的逆转对动物的存活没有不良影响。
Ciliated tracheal epithelium is arranged in a polarized pattern oriented according to the inferior-superior axis of the trachea and is responsible for the transport of mucus toward the larynx. In this study, ciliary beat orientation and the influence of external factors on mucociliary clearance direction were studied in rabbit inverted cervical tracheas.The animals displayed normal respiration postoperatively. After 16 weeks, airway clearance was studied by observation of the movement of silicone particles placed in the inverted segment and in normal parts of the ciliated epithelium. Cilia exhibited unidirectional and coordinated movement within inverted tracheal segments. As shown by the direction of effective flow produced by beating cilia and by scanning electron microscopy, the cilia in the inverted segment beat in the opposite direction from the cilia in the remainder of the trachea. This study demonstrated that ciliary orientation is irreversibly determined, but the reversal of ciliary beating within the cervical trachea had no adverse effects on the survival of the animals.