Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells.
Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells.
复制标题
多药毒素挤出蛋白1基因多态性对其外周血细胞mRNA表达的影响
DOI：
10.1016/j.jphs.2016.03.002
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发表时间：
2016
期刊：
影响因子：
3.5
通讯作者：
Fujimura A.
中科院分区：
文献类型：
--
作者：
Ando H;Nakano K;Ushijima K;Kurokawa S;Washino S;Hosohata K;Morita T;Fujimura A.
本研究旨在确定多药和毒素挤出蛋白1 （MATE1）基因变异对其外周血转录物表达的影响。与之前的体外实验结果一致，与没有这两种启动子变体的受试者相比，携带rs2453579的受试者的MATE1 mRNA水平显著高于携带rs2252281的受试者。此外，mRNA水平在有这两个等位基因的受试者和没有等位基因的受试者之间没有差异。因此，本研究揭示了MATE1基因变异对其mRNA表达的影响可以在活体外周血中检测到。
This study aimed to determine the effect of multidrug and toxin extrusion protein 1 (MATE1) genetic variants on its transcript expression in peripheral blood cells. Consistent with previousin vitrofindings, MATE1 mRNA levels were significantly higher in subjects carrying rs2453579, but not rs2252281, compared to those without either of these promoter variants. In addition, the mRNA levels did not differ between subjects with both variants and those with neither allele. Thus, this study reveals that the influence of MATE1 genetic variants on its mRNA expression can be detectedin vivousing peripheral blood.