Can dual energy X-ray absorptiometry provide a valid assessment of changes in thigh muscle mass with strength training in older adults?
Can dual energy X-ray absorptiometry provide a valid assessment of changes in thigh muscle mass with strength training in older adults?
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DOI：
10.1038/sj.ejcn.1602880
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发表时间：
2008-12-01
影响因子：
4.7
通讯作者：
Conway, J. M.
中科院分区：
文献类型：
--
作者：
Delmonico, M. J.;Kostek, M. C.;Conway, J. M.
目的：确定双能X射线吸收测定法（DXA）与计算机断层扫描（CT）在测量老年人力量训练（ST）后大腿总骨骼肌（SM）质量变化方面的比较。受试者：50名以前久坐、相对健康的老年男性（n = 23，60（标准差）= 7.5）岁）和女性（n = 27，60（s.d. = 9.3）岁）。结果表明，有一个显着增加大腿SM质量与ST测量的两个CT（3.97 +/- 0.4%）和DXA（2.97 +/- 0.6%）方法（均P < 0.001），两种方法之间的百分比变化无显著差异，尽管两种方法之间在基线时存在显着的绝对差异（类似于2公斤）。尽管Bland-Altman图表明DXA与CT方法的大腿SM质量变化百分比之间总体一致，但与DXA相关的3.4%误差大于DXA的大腿SM质量变化。然而，CT测量的变化在大腿SM质量大于其误差（0.6%）。结论：DXA高估基线和ST后大腿SM质量，并可能无法检测到小的变化，大腿SM质量与ST由于其较高的误差。虽然DXA有一定的优势，值得在流行病学和干预研究中使用，但需要改进DXA，以准确评估大腿SM质量的微小变化。
Objective: To determine how dual-energy X-ray absorptiometry (DXA) compares to computed tomography (CT) for measuring changes in total thigh skeletal muscle (SM) mass with strength training (ST) in older adults.Subjects: Fifty previously sedentary, relatively healthy older men (n = 23, 60 (s.d. = 7.5) years) and women (n = 27, 60 (s.d. = 9.3) years).Results: Results indicate that there was a significant increase in thigh SM mass with ST measured by both CT (3.97 +/- 0.4%) and DXA (2.97 +/- 0.6%) methods (both P < 0.001), and there was not a significant difference in percent change between the two methods, although there was a substantial absolute difference (similar to 2 kg) at baseline between the two methods. Although Bland-Altman plots indicate overall agreement between the percent thigh SM mass changes of DXA vs CT methods, the 3.4% error associated with DXA was greater than the thigh SM mass change from DXA. However, the CT measured change in thigh SM mass was greater than its error (0.6%).Conclusions: DXA overestimates baseline and after ST thigh SM mass, and may not be able to detect small changes in thigh SM mass with ST due to its higher error. Although DXA has certain advantages that warrant is used in epidemiologic and intervention studies, improvements to DXA are needed for the accurate assessment of small changes in thigh SM mass.