C-reactive protein and peripheral artery disease among Japanese elderly: The Tsurugaya project
C-reactive protein and peripheral artery disease among Japanese elderly: The Tsurugaya project
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DOI：
10.1291/hypres.27.955
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发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Tsuji, I
中科院分区：
文献类型：
--
作者：
Hozawa, A;Ohmori, K;Tsuji, I
我们在日本老年人中调查了踝臂指数和心血管疾病危险因素，包括C反应蛋白(CRP)的横截面关系，这是一个以前几乎没有流行病学研究的话题。我们的研究人群包括946名年龄至少70岁的受试者，他们同时测量了CRP和踝臂指数。将受试者分为低踝臂指数组(踝臂指数0.9)和正常踝臂指数组。我们发现，当前吸烟、高密度脂蛋白胆固醇40 mg/dl、低体重指数(连续变量)、高血压、糖尿病和他汀类药物的使用都与较低的踝臂指数显著相关。在调整上述心血管危险因素后，较高的对数转换后的CRP水平与较低的踝臂指数显著相关(p<；0.01)。低踝臂指数与0~1个危险因素的OR值分别为5.79(95%可信区间：2.99~11.20)和17.45(95%CI：6.78~49.91)；在不考虑其他危险因素的情况下，CRP1.0 mg/L的OR值为2.10(95%CI：1.13~3.88)。因此，在日本老年人和西方受试者中，高水平的CRP与低的踝臂指数有关。这是首次报道在日本老年人中，C反应蛋白与低踝臂指数之间的关系。
We investigated the cross-sectional relationship between ankle brachial index and cardiovascular disease risk factors, including C-reactive protein (CRP), among Japanese elderly, a topic which has had little prior epidemiologic study. Our study population comprised 946 subjects aged at least 70 years in whom both CRP and ankle brachial index were measured. The participants were classified into a low (ankle brachial index < 0.9) and normal ankle brachial index group. We found that current smoking, high-density lipoprotein cholesterol < 40 mg/dl, a low body mass index (continuous variable), hypertension, diabetes and statin use were all significantly related to a lower ankle brachial index. Higher log-transformed CRP level was significantly related to a lower ankle brachial index after adjustment for the cardiovascular risk factors mentioned above (p < 0.01). The odds ratios for low ankle brachial index compared to 0-1 risk factors were 5.79 (95% confidence interval [CI]: 2.99-11.20) for 2 risk factors and 17.45 (95% CI: 6.78-49.91) for 3 or more risk factors; independently of other risk factors, the odds ratio for CRP > 1.0 mg/l was 2.10 (95% CI: 1.13-3.88) compared to lower CRP values. Thus, a high level of CRP is related to a low ankle brachial index among Japanese elderly as well as Western subjects. This is the first study to report the relationship between CRP and low ankle brachial index among Japanese elderly.