Implantable Devices for the Treatment of Breast Cancer.
Implantable Devices for the Treatment of Breast Cancer.
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DOI：
10.3390/jnt3010003
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发表时间：
2022-03
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乳腺癌是全球女性人口死亡的主要原因之一。化疗等标准治疗显示出明显的效果。然而，它沿着杀死癌细胞的同时，也会引起周围健康细胞的全身毒性和凋亡，因此患者在治疗过程中必须忍受副作用。通过允许利用程序化或受控的药物释放的局部治疗来增强治疗功效的可植入药物递送装置可以克服常规治疗的缺点。可植入装置可由生物聚合物材料、纳米复合材料或两者的组合组成。本文综述了这些类型的植入式设备的最新研究和当前的最新技术水平，并展望了未来的发展方向。
Breast cancer is one of the leading causes of death in the female population worldwide. Standard treatments such as chemotherapy show noticeable results. However, along with killing cancer cells, it causes systemic toxicity and apoptosis of the nearby healthy cells, therefore patients must endure side effects during the treatment process. Implantable drug delivery devices that enhance therapeutic efficacy by allowing localized therapy with programmed or controlled drug release can overcome the shortcomings of conventional treatments. An implantable device can be composed of biopolymer materials, nanocomposite materials, or a combination of both. This review summarizes the recent research and current state-of-the art in these types of implantable devices and gives perspective for future directions.