Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
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DOI：
10.1152/japplphysiol.00474.2005
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Neufer, PD
中科院分区：
文献类型：
--
作者：
DiPietro, L;Dziura, J;Neufer, PD
很少有研究比较中等强度运动训练与较高强度运动训练在保持运动量恒定的情况下改善老年人胰岛素敏感性的相对益处。不运动但不肥胖的健康老年（73 +/- 10 岁）女性（N = 25）被随机分为三个训练计划之一（持续 9 个月）：1）高强度 [80% 峰值有氧能力（V-O2 峰值）； TH]有氧训练； 2）中等强度（65% V-O2峰值；T-M）有氧训练；或 3) 低强度（拉伸）安慰剂对照（50% V-O2 峰值；C-TB）。重要的是，T-H 组和 T-M 组的受试者的运动量（300 kcal/次）保持恒定。 V-O2 峰值是通过在跑步机上使用分级运动挑战来确定的。全身脂肪和瘦体重通过双能 X 射线吸收测定法测定。通过使用两步正常血糖-高胰岛素钳夹，在最后一次运动后 72 小时测定胰岛素刺激的葡萄糖利用率以及脂肪分解的抑制。我们观察到训练后较高胰岛素剂量下葡萄糖利用率有所改善，但与 T-M（16%；P = 0.17）和 C-TB（8%；P = 0.37）组相比，这些改善仅在 T-H（21%；P = 0.02）组中具有统计学意义，并且观察到身体成分或 V-O2 峰值没有变化。同样，在 T-H 组中，我们检测到低胰岛素剂量下胰岛素刺激的脂肪组织脂解抑制 (%) 显着改善（38-55%，P < 0.05）。我们的研究结果表明，与中强度或低强度运动相比，长期高强度运动训练可以为胰岛素作用提供更持久的益处，这可能是由于更大的瞬时效应。
Few studies have compared the relative benefits of moderate- vs. higher intensity exercise training on improving insulin sensitivity in older people while holding exercise volume constant. Healthy older ( 73 +/- 10 yr) women ( N = 25) who were inactive, but not obese, were randomized into one of three training programs ( 9-mo duration): 1) high- intensity [ 80% peak aerobic capacity ( V-O2 peak); TH] aerobic training; 2) moderate- intensity ( 65% V-O2 peak; T-M) aerobic training; or 3) low-intensity ( stretching) placebo control (50% V-O2 peak; C-TB). Importantly, exercise volume ( 300 kcal/session) was held constant for subjects in both the T-H and the T-M groups. V-O2 peak was determined by using a graded exercise challenge on a treadmill. Total body fat and lean mass were determined with dual-energy X-ray absorptiometry. The rate of insulin-stimulated glucose utilization as well as the suppression of lipolysis were determined similar to 72 h after the final exercise bout by using a two-step euglycemic-hyperinsulinemic clamp. We observed improved glucose utilization at the higher insulin dose with training, but these improvements were statistically significant only in the T-H (21%; P = 0.02) compared with the T-M ( 16%; P = 0.17) and C-TB ( 8%; P = 0.37) groups and were observed without changes in either body composition or V-O2 peak. Likewise in the T-H group, we detected a significant improvement in insulin-stimulated suppression (%) of adipose tissue lipolysis at the low-insulin dose ( 38-55%, P < 0.05). Our findings suggest that long-term higher intensity exercise training provides more enduring benefits to insulin action compared with moderate- or low-intensity exercise, likely due to greater transient effects.