Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairment
Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairment
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DOI：
10.1002/jcla.23535
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发表时间：
2020-08-25
影响因子：
2.7
通讯作者：
Li, Haicong
中科院分区：
文献类型：
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作者：
Gao, Menglu;Wang, Qianying;Li, Haicong
背景 本研究的目的是确定严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的敏感指标。方法 采集上海市公共卫生临床中心收治的136例2019冠状病毒病（COVID-19）肺炎患者样本（其中轻症116例，重症20例）。本研究检测了血清尿素、尿酸（UA）、肌酐（CREA）、红细胞沉降率（ESR）、超敏C反应蛋白（hs-CRP）、降钙素原（PCT）和尿蛋白（Pro）的浓度。结果 重症患者尿素（女性7.00+/-3.31，男性8.87+/-5.18）Pro（女性7/7，男性12/13），hs-CRP（女性2/7，男性5/13）ESR（女性94.43+/-33.26，男性67.85+/-22.77）水平高于重症患者轻度（尿素：女性 3.71 +/- 1.00，男性 4.42 +/- 1.14；Pro：女性 3/46，男性 12/70；hs-CRP：女性 1/46，男性 3/70；ESR：女性 43.32 +/- 33.24，男性 21.64 +/- 21.82）。严重组（女性 146.90 +/- 54.01，男性 139.34 +/- 66.95）的 UA 低于轻度组（女性 251.99 +/- 64.35，男性 339.81 +/- 71.32）。 CREA和PCT在轻度和重症患者之间没有显示出显着差异，但我们测试的五种生物标志物（尿素、Pro、hs-CRP、ESR和UA）在轻度和重症患者之间差异很小（P<.05）。结论 重症COVID-19患者尿素、Pro水平较高，而UA水平较低，反映重症患者肾功能较差。然而，hs-CRP、ESR水平较高表明重症患者炎症反应更加活跃。
Background This objective of this study was to identify a sensitive indicator of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods Samples were collected from 136 patients with Coronavirus disease 2019 (COVID-19) pneumonia admitted to the Shanghai public health clinical center (116 mild, 20 severe). The concentrations of serum urea, Uric Acid (UA), Creatinine (CREA), Erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and urine protein (Pro) have been tested in this study. Results Higher levels of urea (female 7.00 +/- 3.31, male 8.87 +/- 5.18) Pro (female7/7, male 12/13), hs-CRP (female 2/7, male 5/13) ESR (female 94.43 +/- 33.26, male 67.85 +/- 22.77) were found in severe patients compared with the mild (urea: female 3.71 +/- 1.00, male 4.42 +/- 1.14; Pro: female 3/46, male 12/70; hs-CRP: female 1/46, male 3/70; ESR: female 43.32 +/- 33.24, male 21.64 +/- 21.82). UA is lower in the severe group (female 146.90 +/- 54.01, male 139.34 +/- 66.95) than in mild group (female 251.99 +/- 64.35, male 339.81 +/- 71.32). CREA and PCT did not show a significant difference between mild and severe patients, but the difference among the five biological markers (urea, Pro, hs-CRP, ESR, and UA) between mild and severe patients we tested was small (P< .05). Conclusion Severe COVID-19 patients had higher levels of urea and Pro, while their UA levels were lower, reflecting poor kidney function in severe patients. However, higher levels of hs-CRP, ESR indicated that inflammatory responses were more active in severe patients.