Quality of Life and a Surveillant Endocannabinoid System.
Quality of Life and a Surveillant Endocannabinoid System.
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DOI：
10.3389/fnins.2021.747229
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发表时间：
2021
影响因子：
4.3
通讯作者：
Trevenzoli IH
中科院分区：
文献类型：
--
作者：
de Melo Reis RA;Isaac AR;Freitas HR;de Almeida MM;Schuck PF;Ferreira GC;Andrade-da-Costa BLDS;Trevenzoli IH
内源性大麻素系统（endocannabinoid system，ECS）是一个重要的脑调节网络。ECS在整个发育过程中调节脑内稳态，从祖细胞命运决定到神经元和胶质细胞生成、突触生成、脑可塑性和回路修复，直到学习、记忆、恐惧、保护和死亡。它是下丘脑-外周系统-脂肪组织中调节食物摄入、能量储存、营养状态和脂肪组织质量的主要参与者，从而影响肥胖。失去ECS控制可能会影响情绪障碍（焦虑症、多动症、精神病和抑郁症），导致药物滥用，并影响神经退行性疾病（阿尔茨海默氏症、帕金森氏症、亨廷顿氏症、多发性硬化症和肌萎缩侧索硬化症）和神经发育（自闭症谱系）障碍。常规的身体和/或身心正念和冥想活动的实践已被证明可以调节内源性大麻素（eCB）水平，以及其他参与者脑源性神经营养因子（BDNF）。ECS涉及疼痛、炎症、代谢和心血管功能障碍、一般免疫应答（哮喘、过敏和关节炎）和肿瘤扩张，在脑和/或外周中。这种巨大影响的原因是，花生四烯酸是eCB的前体，存在于身体的每个膜细胞中，并且根据需要，eCB的合成受到电活动和钙变化的调节。新的脂质（脂氧素和resolvins）或肽（加压素）的ECS球员也作为调节器的生理别稳态。事实上，大麻素受体在细胞内细胞器如线粒体或溶酶体中的存在，或在核靶点如PPARγ中的存在可能会影响能量消耗、代谢和细胞死亡。要过上更好的生活，就需要警惕ECS，通过健康的饮食选择（基于均衡的omega-3和-6多不饱和脂肪酸），每周锻炼和冥想疗法，所有这些都能调节eCB水平，并被建设性的社交网络所包围。大麻二酚是一种饮食补充剂，具有抗炎、抗焦虑、抗抑郁和抗氧化活性。认知挑战和情商可能会加强ECS，ECS是建立在改变人类行为的各种突触上的。在治疗方面，ECS对于维持体内平衡至关重要，大麻素是控制无数靶点的有前途的工具。
The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets.
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影响因子：
11.1
作者：
Alayoubi, Abdulfatah M.;Wang, James C. M.;Medin, Jeffrey A.
通讯作者：
Medin, Jeffrey A.
影响因子：
11.1
作者：
Bartoll A;Toledano-Zaragoza A;Casas J;Guzmán M;Schuchman EH;Ledesma MD
通讯作者：
Ledesma MD
DOI：
10.1101/lm.041608.116
发表时间：
2016-07
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Alteba S;Korem N;Akirav I
通讯作者：
Akirav I
影响因子：
4
作者：
Aso, Ester;Palomer, Ernest;Ferrer, Isidro
通讯作者：
Ferrer, Isidro
影响因子：
3.7
作者：
Almeida, Mariana M.;Dias-Rocha, Camilla P.;Trevenzoli, Isis H.
通讯作者：
Trevenzoli, Isis H.