Effects of a 10-Day Oxytocin Trial in Older Adults on Health and Well-Being
Effects of a 10-Day Oxytocin Trial in Older Adults on Health and Well-Being
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DOI：
10.1037/a0031581
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发表时间：
2013-04-01
影响因子：
2.3
通讯作者：
Zak, Paul J.
中科院分区：
文献类型：
--
作者：
Barraza, Jorge A.;Grewal, Naomi S.;Zak, Paul J.
神经肽催产素（OT）调节下丘脑-垂体-肾上腺（HPA）轴的功能并调节一系列社会过程。临床研究已经使用鼻内OT治疗许多精神疾病引起的症状，包括自闭症、精神分裂症和抑郁症。然而，大多数研究都是基于年轻成年人群的单剂量OT治疗。本研究考察了10天OT对老年人健康和心理健康的影响。居住的老年人（N = 41，平均年龄80岁）被纳入一项随机、双盲、安慰剂对照研究。参与者连续10天接受40 IU鼻内OT或安慰剂治疗。在10天的时间里，没有观察到情绪或心血管状态的变化。重复测量的方差分析显示，在10天内，输注OT的参与者的性格感恩有所改善，而安慰剂对照组的感恩有所下降（p= 0.015）。那些在OT条件下没有报告身体功能随着时间的推移而下降，而在安慰剂条件下观察到（p= 0.05），并且与对照组相比，也报告了更少的疲劳（p= 0.03）。在整个研究中没有明显的不良事件报告，表明OT可以安全地用于老年人。
The neuropeptide oxytocin (OT) modulates functioning of the hypothalamic-pituitary-adrenal (HPA) axis and regulates a range of social processes. Clinical studies have used intranasal OT administration to treat symptoms arising from a number of psychiatric disorders including autism, schizophrenia, and depression. Most of this research, however, has been based on single dose treatments of OT in younger adult populations. The present study examined the impact on the health and psychological well-being of a 10-day OT administration in an older adult population. Residentially housed older adults (N = 41, mean age of 80) were enrolled in a randomized, double-blind, placebo-controlled study. Participants received 40 IU intranasal OT or placebo for 10 consecutive days. No changes in mood or cardiovascular states were observed across the 10-day period. Repeated-measures ANOVAs showed that dispositional gratitude improved for the OT infused participants, although gratitude declined for placebo controls over the 10 days (p=.015). Those in the OT condition did not report a decline in physical functioning over time as was observed in the placebo condition (p=.05), and also reported less fatigue compared with controls (p=.03). No significant adverse events were reported throughout the entirety of the study, indicating that OT can be safely used with older adults.