BOLD responses to visual stimulation in survivors of childhood cancer
BOLD responses to visual stimulation in survivors of childhood cancer
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DOI：
10.1016/j.neuroimage.2004.08.030
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发表时间：
2005-01-01
期刊：
影响因子：
5.7
通讯作者：
Ogg, RJ
中科院分区：
文献类型：
--
作者：
Zou, P;Mulhern, RK;Ogg, RJ
某些癌症幸存的儿童因中枢神经系统 (CNS) 疾病或针对 CNS 的治疗而导致认知缺陷的发生率很高。为了确定使用血氧水平依赖性 (BOLD) 功能磁共振成像 (fMRI) 研究儿童癌症幸存者认知缺陷的可行性，我们测试了以下假设：该人群对视觉刺激具有与健康受试者相同的 BOLD 反应。我们使用 BOLD fMRI 测量了 16 名儿童癌症幸存者、11 名年龄相仿的健康幸存者兄弟姐妹和 16 名健康成年人在短暂视觉刺激后大脑活动的空间和时间模式。使用两种通用线性模型分析幸存者的功能数据，一种使用规范血流动力学响应函数（HRE），另一种使用傅立叶集作为基函数。两种模型的幸存者中测量到的 BOLD 信号和大脑激活模式相似。幸存者的 BOLD 信号在时间和形状上在质量上相似，但与健康受试者相比存在显着的数量差异。 13 名幸存者的激活通常位于初级视觉皮层，但脑肿瘤幸存者的激活体积明显小于其他组。这些发现证明了使用 BOLD fMRI 研究儿童癌症幸存者脑功能的可行性。然而，针对这一人群的功能磁共振成像研究必须考虑到与健康受试者相比，他们的 BOLD 反应的数量差异的影响。 (C) 2004 Elsevier Inc. 保留所有权利。
Children surviving certain cancers have a high incidence of cognitive deficits caused by central nervous system (CNS) disease or treatments directed at the CNS. To establish the feasibility of using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to study cognitive deficits in survivors of childhood cancer, we tested the hypothesis that this population has the same BOLD response to visual stimulation as healthy subjects. We used BOLD fMRI to measure spatial and temporal patterns of brain activity after brief visual stimulation in 16 survivors of childhood cancer, 11 age-similar healthy siblings of survivors, and 16 healthy adults. Functional data for the survivors were analyzed with two general linear models, one used a canonical hemodynamic response function (HRE) and the other used a Fourier set as basis functions. The measured BOLD signal and brain activation patterns were similar in the survivors with both models. The BOLD signal for survivors was qualitatively similar in timing and shape, but there were significant quantitative differences as compared with healthy subjects. The activation was normally located in the primary visual cortex in 13 survivors, but the activation volume was significantly smaller in brain tumor survivors than in other groups. These findings demonstrate the feasibility of using BOLD fMRI to investigate brain function in survivors of childhood cancer. However, fMRI studies in this population must take into account effects of quantitative differences in their BOLD responses as compared to healthy subjects. (C) 2004 Elsevier Inc. All rights reserved.