Corollary discharge inhibition of wind-sensitive cercal giant interneurons in the singing field cricket.
Corollary discharge inhibition of wind-sensitive cercal giant interneurons in the singing field cricket.
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DOI：
10.1152/jn.00520.2014
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发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Hedwig B
中科院分区：
文献类型：
--
作者：
Schöneich S;Hedwig B
蟋蟀的尾索上携带着对风敏感的机械感受器，这些机械感受器对接近的捕食者产生的气流做出反应，通过上升的巨型中间神经元（GI）触发逃避反应。雄性也通过产生气流来激活它们的尾椎系统，气流是由产生声音的翅膀运动产生的。唱歌的雄性仍然会对外部风的刺激做出反应，但不会被自己产生的气流吓到。为了研究神经系统如何区分自我产生的和外部气流的感觉反应，我们在细胞内记录风敏感的传入和腹侧GI的cercal逃避途径在虚构的唱歌蟋蟀，缺乏任何自我刺激的情况。GI尖峰减少每当cercal风刺激与歌唱运动活动相一致。颈传入纤维的轴突终末在歌唱过程中没有表现出突触前抑制的迹象。然而，在两个腹侧地理信息系统，必然的放电抑制发生严格的阶段与歌唱运动模式。配对的细胞内记录显示，这种抑制是不介导的活动，以前确定的必然放电interneuron（CDI），节奏抑制听觉通路在唱歌。然而，尾风刺激，减少了这CDI的突触后抑制的穗活动。我们的研究揭示了如何精确定时的腹侧GI的必然放电抑制可以防止自发气流触发无意中的逃避反应，在唱歌蟋蟀。结果表明，听觉和风敏感通路的反应性调制由不同的CDIs在唱歌蟋蟀和听觉通路中的必然放电抑制可以衰减由cercal风刺激。
Crickets carry wind-sensitive mechanoreceptors on their cerci, which, in response to the airflow produced by approaching predators, triggers escape reactions via ascending giant interneurons (GIs). Males also activate their cercal system by air currents generated due to the wing movements underlying sound production. Singing males still respond to external wind stimulation, but are not startled by the self-generated airflow. To investigate how the nervous system discriminates sensory responses to self-generated and external airflow, we intracellularly recorded wind-sensitive afferents and ventral GIs of the cercal escape pathway in fictively singing crickets, a situation lacking any self-stimulation. GI spiking was reduced whenever cercal wind stimulation coincided with singing motor activity. The axonal terminals of cercal afferents showed no indication of presynaptic inhibition during singing. In two ventral GIs, however, a corollary discharge inhibition occurred strictly in phase with the singing motor pattern. Paired intracellular recordings revealed that this inhibition was not mediated by the activity of the previously identified corollary discharge interneuron (CDI) that rhythmically inhibits the auditory pathway during singing. Cercal wind stimulation, however, reduced the spike activity of this CDI by postsynaptic inhibition. Our study reveals how precisely timed corollary discharge inhibition of ventral GIs can prevent self-generated airflow from triggering inadvertent escape responses in singing crickets. The results indicate that the responsiveness of the auditory and wind-sensitive pathway is modulated by distinct CDIs in singing crickets and that the corollary discharge inhibition in the auditory pathway can be attenuated by cercal wind stimulation.
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影响因子：
0.9
作者：
Kanou, M;Ohshima, M;Inoue, J
通讯作者：
Inoue, J
DOI：
10.1016/s0169-2607(96)01781-6
发表时间：
1997-01-01
影响因子：
6.1
作者：
Knepper, M;Hedwig, B
通讯作者：
Hedwig, B
DOI：
10.1007/s003590050246
发表时间：
1998-08-01
影响因子：
2.1
作者：
Kumagai, T;Shimozawa, T;Baba, Y
通讯作者：
Baba, Y
DOI：
10.1007/bf00197749
发表时间：
1995-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
影响因子：
--
作者：
BABA, Y;HIROTA, K;YAMAGUCHI, T
通讯作者：
YAMAGUCHI, T
影响因子：
2.5
作者：
Hedwig, B
通讯作者：
Hedwig, B