B cell-helping functions of gut microbial metabolites.
B cell-helping functions of gut microbial metabolites.
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DOI：
10.15698/mic2016.10.536
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发表时间：
2016-09-23
期刊：
影响因子：
--
通讯作者：
Kim CH
中科院分区：
文献类型：
--
作者：
Kim CH
共生菌群深刻影响宿主免疫系统。长期以来，人们一直观察到共生菌通过产生B细胞受体（BCR）抗原和toll样受体（TLR）配体来增强宿主体内抗体的产生。我们最近报道了微生物代谢物短链脂肪酸（SCFAs）调节B细胞的代谢和基因表达以促进抗体的产生（Kim等）。肠道微生物代谢物促进宿主抗体反应。《细胞宿主与微生物》2016；20(2): 202 - 14)。本文讨论了SCFAs的b细胞辅助功能及其在宿主免疫系统中的意义。
Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites short-chain fatty acids (SCFAs) regulate the metabolism and gene expression in B cells to promote antibody production (Kim et al. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host & Microbe. 2016; 20(2):202-14). The B-cell helping function of SCFAs and its implication in the host immune system are discussed in this article.