Body Composition Trajectories From Infancy to Preschool in Children Born Premature Versus Full-term
Body Composition Trajectories From Infancy to Preschool in Children Born Premature Versus Full-term
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DOI：
10.1097/mpg.0000000000001494
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发表时间：
2017-06-01
影响因子：
2.9
通讯作者：
Ramel, Sara E.
中科院分区：
文献类型：
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作者：
Scheurer, Johannah M.;Zhang, Lei;Ramel, Sara E.
目的：本研究的目的是纵向描述早产儿与足月儿从婴儿期到学龄前的身体成分轨迹，以及早期脂肪和无脂肪体重增加与学龄前身体成分的关系。方法：对一组适合胎龄的早产儿 (n = 20) 和足月儿 (n = 51) 进行 3 次随访：“新生儿”随访 1 次是在 2 周龄足月婴儿和近足月校正年龄时进行早产； “婴儿期”访问 2 时 3 至 4 个月（早产校正年龄）； “学前班”访问 3 至 4 岁。在所有访问中均通过排气体积描记法和人体测量学测量身体成分。使用皮尔逊偏相关系数对婴儿体重和身体成分与学前测量的跟踪进行了测试。使用多元线性回归评估连续身体成分测量之间的关联。结果：早产儿（平均胎龄 31.9 周，平均出生体重 1843 克）和足月（平均胎龄 39.8 周）婴儿之间的身体成分早期差异在学龄前并不存在。早产儿第 1 次访视的身体成分与学前测量结果不相关。第 2 次访问测量结果与学前测量结果相关。从访视 1 到访视 2 的去脂体重增加与早产儿的学龄前瘦体重呈正相关（β=0.038，P=0.049），而脂肪增加与学龄前身体成分无关。结论：早产儿和足月儿在学龄前的身体成分相似。对于早产儿来说，无脂体重增加（而非肥胖增加）与学龄前无脂体重呈正相关；这可能与后期肥胖和不良代谢结果的风险降低有关。
Objectives: The aim of the study was to longitudinally characterize infancy to preschool body composition trajectories and the association of early fat and fat-free mass gains with preschool age body composition in children born premature versus full-term.Methods: A cohort of appropriate-for-gestational age preterm (n = 20) and term (n = 51) infants were followed at 3 visits: "neonatal" visit 1 at 2 weeks of age for term and near term corrected age for preterm; "infancy" visit 2 at 3 to 4 months (preterm corrected age); "preschool" visit 3 at 4 years. Body composition via air displacement plethysmography and anthropometrics were measured at all visits. Tracking of infancy weight and body composition with preschool measurements was tested using Pearson partial correlation coefficients. Associations between serial body composition measurements were assessed using multiple linear regression.Results: Early differences in body composition between premature (mean gestational age 31.9 weeks, mean birth weight 1843 g) and full-term (mean gestational age 39.8 weeks) infants were not present at preschool age. Visit 1 body composition was not correlated with preschool measurements in the preterm infants. Visit 2 measurements were correlated with preschool measures. Fat-free mass accretion from visit 1 to visit 2 was positively associated with preschool lean mass (beta = 0.038, P = 0.049) in preterm children, whereas fat accretion was not associated with preschool body composition.Conclusions: Children born prematurely and full-term have similar body composition at preschool age. For preterms infancy fat-free mass gains, and not adiposity gains, are positively associated with preschool fat-free mass; this may be associated with lower risk of later obesity and adverse metabolic outcomes.