NSF and p97/VCP: similar at first, different at last
NSF and p97/VCP: similar at first, different at last
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DOI：
10.1016/s0014-5793(03)01107-4
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发表时间：
2003-11-27
期刊：
影响因子：
3.5
通讯作者：
DeLaBarre, B
中科院分区：
文献类型：
--
作者：
Brunger, AT;DeLaBarre, B
N-Ethylmaleimide sensitive factor (NSF) and p97/ valosin-containing protein (VCP) are distantly related members of the ATPases associated with a variety of cellular activities (AAA) family of proteins. While both proteins have been implied in cellular morphology changes involving membrane compartments or vesicles, more recent evidence seems to imply that NSF is primarily involved in the soluble NSF attachment receptor (SNARE)-mediated vesicle fusion by disassembling the SNARE complex whereas p97/VCP is primarily involved in the extraction of membrane proteins. These functional differences are now corroborated by major structural differences based on recent crystallographic and cryo-electron microscopy studies. This review discusses these recent findings. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
