Plasma exchange and prednisone in Guillain‐Barré syndrome
Plasma exchange and prednisone in Guillain‐Barré syndrome
复制标题
格林-巴利综合征的血浆置换和泼尼松
DOI：
10.1212/wnl.35.11.1551
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发表时间：
1985
期刊：
影响因子：
9.9
通讯作者：
Tulio E. Bertorini
中科院分区：
文献类型：
--
作者：
J. Mendell;J. Kissel;M. Kennedy;Z. Sahenk;H. Grinvalsky;G. Pittman;R. Kyler;R. Roelofs;J. N. Whitaker;Tulio E. Bertorini
对格林-巴利́综合征(格林-巴利综合征)患者进行了血浆置换联合泼尼松与单纯支持治疗的对照随机试验。与对照组相比，治疗组没有显著改善。尽管样本量很小(12个治疗组和13个对照组)，但有能力(95%的机会)检测到两组之间英国医学研究委员会强度等级的变化。我们的结果与其他表明血浆交换有益效果的结果的差异可能反映了泼尼松对GBS恢复的不利影响。未能在我们的患者中发现血浆交换的好处也增加了GBS可能是一种异质性疾病的可能性，体液因素在部分但不是所有患者中发挥作用。
A controlled randomized trial of plasma exchange combined with prednisone was compared with supportive care alone in patients with Guillain-Barré syndrome (GBS). There was no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of 2 British Medical Research Council grades of strength between the groups. The difference in our results and others that indicated a beneficial effect of plasma exchange may reflect an adverse effect of prednisone on recovery in GBS. Failure to find a benefit of plasma exchange in our patients also raises the possibility that GBS may be a heterogeneous disorder with humoral factors playing a role in some but not all patients.