CD24 Expression is Associated with Progression of Gastric Cancer
CD24 Expression is Associated with Progression of Gastric Cancer
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DOI：
10.5754/hge12763
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发表时间：
2013-06-01
影响因子：
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通讯作者：
Kato, Hiroyuki
中科院分区：
文献类型：
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作者：
Takahashi, Masakazu;Nakajima, Masanobu;Kato, Hiroyuki
背景/目的：日本胃癌死亡率很高。为了改善患者预后，迫切需要新的诊断和治疗生物标志物。在这项研究中，我们研究了 CD24 的作用，CD24 是一种与肿瘤细胞增殖有关的细胞粘附糖蛋白，可用作各种癌症的预后标志物。方法：我们通过免疫组织化学分析了 173 例胃腺癌中的 CD24 表达，并将数据与临床病理参数和患者总生存期进行了比较。此外，我们对六种人胃腺癌细胞系 Kato III、MKN1、MKN28、MKN45、MKN74 和 HGC-27 中的 CD24 进行了蛋白质印迹分析。结果：CD24 上调与浸润深度 (p=0.005) 和病理高分期 (p=0.043) 显着相关。我们观察到CD24高表达与淋巴结转移、静脉侵犯和淋巴管侵犯之间的关系。 CD24 表达在分化型胃癌细胞系（包括淋巴结转移细胞系）中往往较高。结论：我们的研究表明，应密切监测 CD24 高表达的胃癌患者切除后的复发情况。 CD24表达是胃癌预后的潜在生物标志物，并为治疗策略提供了新的分子靶点。
Background/Aims: Mortality rates due to gastric cancer are high in Japan. To improve patient prognosis, new biomarkers for diagnosis and treatment are urgently required. In this study we investigated the role of CD24, a cell adhesion glycoprotein implicated in tumor cell proliferation, which is used as a prognostic marker in various cancers. Methodology: We analyzed CD24 expression in 173 gastric adenocarcinomas by immunohistochemistry and compared the data with clinicopathological parameters and patient overall survival. Furthermore, we performed Western blotting analysis of CD24 in six human gastric adenocarcinoma cell lines, Kato III, MKN1, MKN28, MKN45, MKN74, and HGC-27. Results: CD24 up-regulation was significantly correlated with depth of invasion (p=0.005) and pathological high stages (p=0.043). We observed a relationship between high CD24 expression and lymph node metastasis, venous invasion and lymphatic invasion. CD24 expression tended to be higher in cell lines derived from differentiated gastric carcinoma, including those derived from lymph node metastasis. Conclusions: Our study suggests that gastric cancer patients with high CD24 expression should be closely monitored for recurrence following resections. CD24 expression is a potential biomarker for gastric cancer prognosis and provides a new molecular target for therapeutic strategies.