AGE AND SEX AFFECT SPATIAL AND EMOTIONAL BEHAVIORS IN RATS: THE ROLE OF REPEATED ELEVATED PLUS MAZE TEST
AGE AND SEX AFFECT SPATIAL AND EMOTIONAL BEHAVIORS IN RATS: THE ROLE OF REPEATED ELEVATED PLUS MAZE TEST
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DOI：
10.1016/j.neuroscience.2012.09.036
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发表时间：
2012-12-27
期刊：
影响因子：
3.3
通讯作者：
Gokbel, H.
中科院分区：
文献类型：
--
作者：
Belviranli, M.;Atalik, K. E. N.;Gokbel, H.
本研究的主要目的是探讨年龄和性别差异对大鼠运动活动、学习和记忆的影响。另一个目的是研究反复升高的迷宫测试是否会引起大鼠的焦虑。80只Wistar大鼠按性别、年龄、焦虑状态分为8组。在野外评估运动活动。在高架加迷宫中进行重复焦虑测试。Morris水迷宫评价空间学习记忆能力。所有行为测试在线记录，并通过分析软件离线分析。焦虑诱导的大鼠探索性行为较低。与雌性相比，雄性大鼠的焦虑水平、运动活动和探索行为较低。在Morris水迷宫潜伏期寻找平台训练期间，各重复测试组的总行走距离和平均游泳速度均有所下降，幼龄大鼠普遍快于老龄大鼠。在探针试验期间，虽然穿越站台的次数没有受到影响，但在站台区域停留的时间在年轻人组中比在老年人组中要高。总之，年龄和性别对运动活动、学习记忆有不同的影响。(c) 2012 ibro。Elsevier Ltd.出版。版权所有。
The main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, age and anxiety status. Locomotor activity was assessed in open field. Repeated anxiety tests were performed in elevated plus maze. Spatial learning and memory were evaluated with the Morris water maze. All behavioral tests were recorded online and analyzed offline with an analytical software. Exploratory behavior was lower in anxiety-induced rats. Male rats had lower anxiety levels, locomotor activity and exploratory behavior compared to females. During the training period of Morris water maze latency to find platform, total distance traveled and average swimming speed decreased in all groups with repeated tests and young rats generally were faster than aged rats. During the probe trial, although the number of platform crossings was not affected, time spent in the platform zone was higher in the young groups compared to the aged groups. In conclusion, age and sex affect locomotor activity, learning and memory in different aspects. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.