Blockade of IL-6 Secretion Pathway by the Sesquiterpenoid Atractylenolide III
Blockade of IL-6 Secretion Pathway by the Sesquiterpenoid Atractylenolide III
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DOI：
10.1021/np100686a
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发表时间：
2011-02-01
影响因子：
5.1
通讯作者：
Jeong, Hyun-Ja
中科院分区：
文献类型：
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作者：
Kang, Tae-Hee;Han, Na-Ra;Jeong, Hyun-Ja
其中，白术Ⅲ（1）是白术的主要活性成分。本研究的目的是分析1。该倍半萜类化合物抑制佛波醇12-肉豆蔻酸酯13-乙酸酯和钙离子载体A23187刺激的人肥大细胞（HMC）-1中IL-6的分泌和表达。此外，1抑制组胺释放刺激HMC-1细胞。在刺激的HMC-1细胞中，1抑制p38丝裂原活化蛋白激酶、C-Jun-N-末端蛋白激酶和核因子-κ B的活化。此外，1抑制caspase-1的激活和受体相互作用蛋白-2的表达。这些结果提供了新的见解，即阿替沙星III（1）可能通过调节肥大细胞中IL-6的细胞功能来控制免疫反应。
Atractylenolide III (1) is the major bioactive component of Atractylodes lancea. The aim of this study was to analyze the effect on the regulation of interleukin (IL)-6 secretion pathway caused by 1. This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. In addition, 1 inhibited histamine release in stimulated HMC-1 cells. In stimulated HMC-1 cells, 1 suppressed activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-kappa B. In addition, 1 suppressed the activation of caspase-1 and the expression of receptor interacting protein-2. These results provide new insights that atractylenolide III (1) may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.