Perceptual learning, awareness, and the hippocampus
Perceptual learning, awareness, and the hippocampus
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DOI：
10.1002/hipo.1093
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Squire, LR
中科院分区：
文献类型：
--
作者：
Manns, JR;Squire, LR
陈述性记忆依赖于海马体以及相关的内侧颞叶和间脑结构。人们通常发现，陈述性记忆可用于有意识的回忆。最近的一项研究(Chun和菲尔普斯，NAT Neurosci 1999；2：844-847)发现，内侧颞叶(包括海马体)的损伤会损害知觉学习任务的表现，但学习是在缺乏对刺激的记忆的情况下完成的。这一发现提出了一种可能性，即一些依赖海马体的任务可能无法被意识到，并且可能在没有唤起有意识的记忆过程的情况下执行。使用同样的任务，我们表明，当损伤主要局限于海马体结构时，知觉学习是完整的。因此，现有数据表明，仅限于海马体结构的损伤不会损害无意识(非陈述性)记忆。此外，这些数据与海马体依赖记忆是有意识的记忆这一观点并不矛盾。最后，患者的知觉学习受损，内侧颞叶广泛受损，外侧颞叶皮质也有不同程度的损害。海马体2001；11：776-782。2001年出版，Wiley-Liss，Inc.(Dagger)。
Declarative memory depends on the hippocampus and related medial temporal lobe and diencephalic structures. Declarative memory has usually been found to be available to conscious recollection. A recent study (Chun and Phelps, Nat Neurosci 1999;2:844-847) found that damage to the medial temporal lobe (including the hippocampus) impaired performance on a perceptual learning task, yet the learning was accomplished in the absence of memory for the stimuli. This finding raised the possibility that some hippocampus-dependent tasks may be inaccessible to awareness and may be performed without evoking conscious memory processes. Using the same task, we show that when damage is confined largely to the hippocampal formation, perceptual learning is intact. Thus, the available data suggest that damage limited to the hippocampal formation does not impair nonconscious (nondeclarative) memory. Further, the data do not contradict the idea that hippocampus-dependent memory is accessible to conscious recollection. Finally, perceptual learning was impaired in patients, with extensive damage to the medial temporal lobe and with additional variable damage to lateral temporal cortex. Hippocampus 2001;11:776-782. Published 2001 Wiley-Liss, Inc.(dagger).