Connexin-based signaling and drug-induced hepatotoxicity.
Connexin-based signaling and drug-induced hepatotoxicity.
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DOI：
10.18053/jctres.03.2017s1.004
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Vinken M
中科院分区：
文献类型：
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作者：
Maes M;Vinken M
连接蛋白及其通道是维持肝脏稳态的重要介质，常参与肝脏毒性的发生。在本文中，特别注意肝毒性药物对这些通信结构的作用。在第一部分中，概述了连接蛋白为基础的通道在肝脏中的结构，调节和功能特性。在第二部分中，对乙酰氨基酚，降血脂药物，苯巴比妥和美沙吡林对连接蛋白信号的影响进行了讨论。此外，这一主题的临床和体外毒理学领域的相关性得到证明。患者相关性：连接蛋白信号传导在药物诱导的肝毒性中的作用可能具有高度的临床相关性，因为它通过干扰连接蛋白通道开放为治疗性治疗此类损伤提供了前景。
Being critical mediators of liver homeostasis, connexins and their channels are frequently involved in liver toxicity. In the current paper, specific attention is paid to actions of hepatotoxic drugs on these communicative structures. In a first part, an overview is provided on the structural, regulatory and functional properties of connexin-based channels in the liver. In the second part, documented effects of acetaminophen, hypolipidemic drugs, phenobarbital and methapyriline on connexin signaling are discussed. Furthermore, the relevance of this subject for the fields of clinical and in vitro toxicology is demonstrated. Relevance for patients: The role of connexin signaling in drug-induced hepatotoxicity may be of high clinical relevance, as it offers perspectives for the therapeutic treatment of such insults by interfering with connexin channel opening.