Crosslinking strategies for preparation of extracellular matrix-derived cardiovascular scaffolds.
Crosslinking strategies for preparation of extracellular matrix-derived cardiovascular scaffolds.
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DOI：
10.1093/rb/rbu009
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发表时间：
2014-11
影响因子：
6.7
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Ma B;Wang X;Wu C;Chang J
人工心脏瓣膜血管置换术是治疗终末期心血管疾病的有效方法。天然细胞外基质（ECM）衍生材料（脱细胞异体或异种组织）作为心血管支架受到广泛关注。然而，生物假体移植物通常不太耐用，并且会发生钙化和进行性结构退化。戊二醛（GA）是一种常用的交联剂，用于提高天然支架材料的生物相容性和耐久性。然而，ECM和ga交联材料的性质可能导致钙化，最终导致移植失败。因此，人们对新型交联剂进行了研究。本文主要综述了ecm衍生的心血管支架及其交联策略的研究进展。
Heart valve and blood vessel replacement using artificial prostheses is an effective strategy for the treatment of cardiovascular disease at terminal stage. Natural extracellular matrix (ECM)-derived materials (decellularized allogeneic or xenogenic tissues) have received extensive attention as the cardiovascular scaffold. However, the bioprosthetic grafts usually far less durable and undergo calcification and progressive structural deterioration. Glutaraldehyde (GA) is a commonly used crosslinking agent for improving biocompatibility and durability of the natural scaffold materials. However, the nature ECM and GA-crosslinked materials may result in calcification and eventually lead to the transplant failure. Therefore, studies have been conducted to explore new crosslinking agents. In this review, we mainly focused on research progress of ECM-derived cardiovascular scaffolds and their crosslinking strategies.