Medial temporal lobe atrophy in vascular dementia: Visual temporal lobe rating scale
Medial temporal lobe atrophy in vascular dementia: Visual temporal lobe rating scale
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DOI：
10.1016/j.archger.2008.03.014
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发表时间：
2009-05-01
影响因子：
4
通讯作者：
Seo, Hyun-Jin
中科院分区：
文献类型：
--
作者：
Cho, Hyun;Kwon, Jee-Hyun;Seo, Hyun-Jin
核磁共振成像(MRI)评估的内侧颞叶萎缩(MTA)可以通过几种方法进行测量。首先，视觉评分表是一种快速、简便的测量方法。MTA是阿尔茨海默病(AD)的敏感标记物，但不具特异性。它在包括血管性痴呆(VD)在内的其他痴呆症中也有文献记载。本研究旨在用标准化的视觉评定量表评估VD患者MTA的程度，并提示MTA在VD中可能发挥的作用。对25例VD、33例AD和27例非痴呆患者进行了冠状位三维磁化快速梯度回波脑MRI序列扫描。MTA的视觉评分从0分(无萎缩)到4分(严重萎缩)。平均MTA总分AD组为5.39分，VD组为2.16分，非痴呆组为0.56分。大多数VD患者(80%)有MTA表现。双侧较非痴呆组大，但较AD组轻。此外，左侧评分的MTA与年龄显著相关。视觉测量的内侧颞叶体积在VD患者中较小，尽管程度不同于AD患者。提示VD患者的MTA可能与既往存在的AD有关。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Medial temporal lobe atrophy (MTA) as assessed by magnetic resonance imaging (MRI) can be measured in several ways. First of all, visual rating scale is a quick and easy measurement. MTA is a sensitive marker for Alzheimer's disease (AD), but not specific. It has been documented in other dementias including vascular dementia (VD). This study is to evaluate the degree of MTA in VD patients using a standardized visual rating scale and to suggest the importance of the possible role of MTA in VD. Twenty-five VD, 33 AD and 27 non-demented patients underwent a coronal three-dimensional magnetization prepared rapid gradient echo brain MRI sequence. MTA was rated visually using a 5-point rating scale from 0 (no atrophy) to 4 (severe atrophy). The mean summed MTA score was 5.39 in AD, 2.16 in VD and 0.56 in non-demented patients. Most of the VD patients (80%) showed MTA. They were greater in bilateral sides compared with the non-demented group, but milder than in AD. Additionally, MTA of left side score was significantly associated with age. Medial temporal lobe volumes measured visually are smaller in size in patients with VD, although not to the same extent as in AD. This suggests that MTA in VD patients may be associated with pre-existing AD. (c) 2008 Elsevier Ireland Ltd. All rights reserved.