Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.
Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.
复制标题
血吸虫病肝纤维化：卵肉芽肿在体外分泌成纤维细胞刺激因子。
作者：
D. Wyler;S. Wahl;L. Wahl
曼氏血吸虫感染小鼠肝脏分离的虫卵肉芽肿的胞浆提取物和培养上清液刺激成纤维细胞掺入氚胸苷并在体外增殖。这一发现表明，肝脏肉芽肿可能在调节曼氏血吸虫感染时的肝纤维化中发挥作用。
Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.