Chronic Insomnia and the Stress System
Chronic Insomnia and the Stress System
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DOI：
10.1016/j.jsmc.2007.04.002
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发表时间：
2007-06-01
影响因子：
2.8
通讯作者：
Vgontzas, Alexandros N.
中科院分区：
文献类型：
--
作者：
Basta, Maria;Chrousos, George P.;Vgontzas, Alexandros N.
失眠是一种非常常见的睡眠障碍，客观的睡眠测量、脑电图活动、生理学发现、HPA轴活动和炎症标志物表明，这不是一种睡眠不足的状态，而是一种在夜间和白天都存在的过度觉醒障碍。一些心理和生理因素会导致失眠的发生和持续，例如焦虑-沉思型人格特征、压力事件、与年龄相关的睡眠稳态削弱机制、更年期和中枢神经系统过度觉醒的生物遗传素质。失眠的治疗方法应该是多维的，减少整个 24 小时睡眠/觉醒期间的整体情绪和生理过度兴奋及其潜在因素。
In insomnia, which is a very common sleep disorder, objective sleep measures, EEG activity, physiologic findings, HPA axis activity, and inflammation markers suggest that it is not a state of sleep loss, but a disorder of hyperarousal present both during the night and the daytime. Several psychological and physiological factors contribute to the onset and perpetuation of insomnia, such as anxious-ruminative personality traits, stressful events, age-related sleep homeostasis weakening mechanisms, menopause, and biologic-genetic diathesis of CNS hyperarousal. The therapeutic approach in insomnia should be multidimensional, reducing the overall emotional and physiologic hyperarousal and its underlying factors present throughout the 24-hour sleep/wake period.