Prevalence and Incidence of Parkinson's Disease in Latin America: A Meta-Analysis.
Prevalence and Incidence of Parkinson's Disease in Latin America: A Meta-Analysis.
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拉丁美洲帕金森病的患病率和发病率：荟萃分析。
DOI：
10.1002/mds.29682
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Prina,Matthew
中科院分区：
文献类型：
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作者：
Kim,DaniJ;Isidro-Pérez,AnaL;Doering,Michelle;Llibre-Rodriguez,JuanJ;Acosta,Isaac;RodriguezSalgado,AnaM;Pinilla-Monsalve,GabrielD;Tanner,Caroline;Llibre-Guerra,JorgeJ;Prina,Matthew
背景帕金森病（PD）是一种迅速发展的神经退行性疾病，但在拉丁美洲缺乏最新的流行病学数据。我们试图估计PD和帕金森综合征在拉丁美洲的患病率和发病率。方法我们检索Medline，Embase，Scopus，Web of Science，Scientific Electronic Library Online，和Literatura Latino-Americana e do Caribe em Ciências da Saúde或拉丁美洲和加勒比健康科学文献数据库，用于流行病学研究，报告拉丁美洲PD或帕金森症的患病率或发生率，从开始到2022.研究的质量使用乔安娜布里格斯研究所（JBI）的关键评估清单进行评估。通过随机效应Meta分析汇总数据，并按数据来源（队列研究或管理数据库）、性别和年龄组进行分析。两组之间的显着差异进行了确定Meta‐regression.ResultsEighteen来自13个拉丁美洲国家的研究被列入审查。17项研究的Meta分析（近400万参与者）发现患病率为472（95% CI，271-820）/100，000，3项研究的发生率为31（95% CI，23-40）; 7项研究发现帕金森综合征的患病率为4300（95% CI，1863-9613）/100，000人年。PD的患病率因数据来源而异（队列研究，733 [95% CI，427-1255] vs.管理数据库）。114 [95%CI，63-209]/100，000，P< 0.01），年龄组（P< 0.01），但不包括性别（P= 0.73）。不同数据来源（队列研究）的≥60岁PD患病率也存在显著差异。1229 [95%CI，741-2032] vs.管理数据库，593 [95%CI，480-733]/100，000，P< 0.01）。类似的模式，观察parkinsonism.ConclusionsThe PD在拉丁美洲的总体患病率和发病率进行了估计。PD患病率在数据来源和年龄方面存在显著差异，但在性别方面无显著差异。© 2023 The Authors.Movement Disorder由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版。
BackgroundParkinson's disease (PD) is a rapidly growing neurodegenerative disorder, but up‐to‐date epidemiological data are lacking in Latin America. We sought to estimate the prevalence and incidence of PD and parkinsonism in Latin America.MethodsWe searched Medline, Embase, Scopus, Web of Science, Scientific Electronic Library Online, and Literatura Latino‐Americana e do Caribe em Ciências da Saúde or the Latin American and Caribbean Health Science Literature databases for epidemiological studies reporting the prevalence or incidence of PD or parkinsonism in Latin America from their inception to 2022. Quality of studies was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Data were pooled via random‐effects meta‐analysis and analyzed by data source (cohort studies or administrative databases), sex, and age group. Significant differences between groups were determined by meta‐regression.ResultsEighteen studies from 13 Latin American countries were included in the review. Meta‐analyses of 17 studies (nearly 4 million participants) found a prevalence of 472 (95% CI, 271–820) per 100,000 and three studies an incidence of 31 (95% CI, 23–40) per 100,000 person‐years for PD; and seven studies found a prevalence of 4300 (95% CI, 1863–9613) per 100,000 for parkinsonism. The prevalence of PD differed by data source (cohort studies, 733 [95% CI, 427–1255] vs. administrative databases. 114 [95% CI, 63–209] per 100,000,P< 0.01), age group (P< 0.01), but not sex (P= 0.73). PD prevalence in ≥60 years also differed significantly by data source (cohort studies. 1229 [95% CI, 741–2032] vs. administrative databases, 593 [95% CI, 480–733] per 100,000,P< 0.01). Similar patterns were observed for parkinsonism.ConclusionsThe overall prevalence and incidence of PD in Latin America were estimated. PD prevalence differed significantly by the data source and age, but not sex. © 2023 The Authors.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.