EFFECTS OF ANDROGEN ON THE GLANS PENIS AND MATING BEHAVIOR OF CASTRATED MALE RATS
EFFECTS OF ANDROGEN ON THE GLANS PENIS AND MATING BEHAVIOR OF CASTRATED MALE RATS
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DOI：
10.1002/jez.1401140108
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发表时间：
1950-01-01
影响因子：
--
通讯作者：
LEVINSON, G
中科院分区：
文献类型：
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作者：
BEACH, FA;LEVINSON, G
雄性成年大鼠去势后分为4组，其中3组给予不同amts。丙酸睾丸酮的剂量而对照组用惰性油处理。Exptl的影响。阴茎头的治疗包括皮质骨，生殖乳头数量的变化，如果不给予雄激素，在小激素剂量的影响下数量减少，而在接受较大amt的动物中保持正常。雄激素数据来自早期的实验。对去势大鼠交配行为的研究表明，阴茎头的解剖变化与性表现的变化密切相关。龟头的组织学研究表明，生殖乳头可能作为附属感觉结构，通过刺激位于其下方的触觉神经末梢。未治疗的阉割和接受次优amts的雄性的性行为减少。外源性雄激素的减少被解释为部分是由于交配器官的敏感性降低。即使目前的假设是正确的，阉割和替代疗法的行为后果也不能完全用生殖器敏感性的改变来解释。其他证据表明，雄激素的作用是通过一系列复杂的机制来介导的，龟头的触觉功能只是其中之一。
Adult male rats were castrated and divided into 4 groups, 3 of which received different amts. of testosterone propionate by daily injn. while a control group was treated with inert oil. Effects of the exptl. treatment of the glans penis included changes in the number of cornified, genital papillae which tended to disappear if no androgen was admd., to decrease in number under the influence of small hormone dosages, and to remain normal in animals receiving larger amts. of androgen. Data taken from an earlier expt. on mating behavior of castrated rats showed that changes in the anatomy of the glans and changes in sexual performance are closely related. Histological study of the glans suggests that the genital papillae may act as accessory sensory structures, by stimulating tactile nerve endings that lie beneath them. The decreased sexual behavior in untreated castrates and in males receiving sub-optimal amts. of exogenous androgen is interpreted as being due in part to lowered sensitivity in the copulatory organ. Even if the present hypothesis is correct, the behavioral consequences of castration and replacement therapy cannot be explained entirely in terms of altered genital sensitivity. Other evidence makes it plain that the effects of androgen are mediated by a complex combination of mechanisms, of which the supposed tactile functions of the glans are only one.