Near-infrared signals associated with electrical stimulation of peripheral nerves.
Near-infrared signals associated with electrical stimulation of peripheral nerves.
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与周围神经电刺激相关的近红外信号。
DOI：
10.1117/12.809428
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Bergethon,PeterR
中科院分区：
文献类型：
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作者：
Fantini,Sergio;Chen,DebbieK;Martin,JeffreyM;Sassaroli,Angelo;Bergethon,PeterR
我们报告了我们的研究的光信号测量非侵入性的电刺激周围神经。刺激包括将0.1 ms电流脉冲（低于触发任何可见运动的阈值）输送到人类受试者的外周神经（我们已经研究了腓肠神经和正中神经）。响应于电刺激，我们观察到在刺激后约100 ms达到峰值的光信号，其时间尺度比电响应或感觉神经动作电位（SNAP）的几毫秒持续时间长得多。虽然我们测量的100 ms光信号不是神经激活的直接光学特征，但它仍然指示对神经激活的介导响应。我们认为，这可能会提供有用的信息，了解起源的快速光信号（也在100毫秒的时间尺度），已被测量非侵入性的大脑中响应大脑激活。此外，对周围神经激活的光学响应可以发展成周围神经病变的诊断工具，如在糖尿病神经病变患者中相对于正常受试者（平均峰值时间：160 ms）测量的延迟光学信号（平均峰值时间：230 ms）所表明的。
We report our studies on the optical signals measured non-invasively on electrically stimulated peripheral nerves. The stimulation consists of the delivery of 0.1 ms current pulses, below the threshold for triggering any visible motion, to a peripheral nerve in human subjects (we have studied the sural nerve and the median nerve). In response to electrical stimulation, we observe an optical signal that peaks at about 100 ms post-stimulus, on a much longer time scale than the few milliseconds duration of the electrical response, or sensory nerve action potential (SNAP). While the 100 ms optical signal we measured is not a direct optical signature of neural activation, it is nevertheless indicative of a mediated response to neural activation. We argue that this may provide information useful for understanding the origin of the fast optical signal (also on a 100 ms time scale) that has been measured non-invasively in the brain in response to cerebral activation. Furthermore, the optical response to peripheral nerve activation may be developed into a diagnostic tool for peripheral neuropathies, as suggested by the delayed optical signals (average peak time: 230 ms) measured in patients with diabetic neuropathy with respect to normal subjects (average peak time: 160 ms).