Metallic implant-associated lymphoma: a distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma?
Metallic implant-associated lymphoma: a distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma?
复制标题
金属植入物相关淋巴瘤：与脓胸相关淋巴瘤相关的大 B 细胞淋巴瘤的独特亚组？
DOI：
--
复制
发表时间：
2005
影响因子：
5.6
通讯作者：
H. Yiu
中科院分区：
文献类型：
--
作者：
W. Cheuk;A. Chan;J. Chan;G. Lau;V. N. Chan;H. Yiu
发生在金属植入物部位的原发性非霍奇金淋巴瘤非常罕见，尽管多年的研究，但植入物的金属组件和磨损颗粒可能的致癌作用尚未得到回答。我们报告一例大B细胞淋巴瘤发生在一个78岁的男子谁有超过30年的膝关节假体植入。淋巴瘤为显微镜大小，在松动假体的手术翻修时取出的磨屑中偶然发现。该淋巴瘤表达CD20，免疫球蛋白基因克隆性重排，并携带EB病毒（EBV）。该病例与先前报告的病例一起表明，金属植入物相关淋巴瘤是大B细胞淋巴瘤的一个独特亚组，与脓胸相关淋巴瘤和骨髓炎相关淋巴瘤有许多相似之处，因为淋巴瘤是在有限的身体空间中慢性炎症或刺激的情况下产生的EBV相关大B细胞淋巴瘤。
Primary non-Hodgkin lymphoma arising at the site of metallic implant is very rare, and the possible carcinogenic effects of the metallic components and wear particles of the implant have not been answered despite many years of investigation. We report a case of large B-cell lymphoma occurring in a 78-year-old man who had a knee prosthesis implant for more than 30 years. The lymphoma was of microscopic size and found incidentally in the wear debris removed at surgical revision of the loosened prosthesis. The lymphoma expressed CD20, showed clonal rearrangements of immunoglobulin gene, and harbored Epstein-Barr virus (EBV). This case, together with previously reported cases, suggests that metallic implant-associated lymphoma is a distinctive subgroup of large B-cell lymphoma that shares many similarities with pyothorax-associated lymphoma and osteomyelitis-associated lymphoma, in that the lymphoma is an EBV-associated large B-cell lymphoma arising in a setting of chronic inflammation or irritation in a confined body space.
影响因子：
158.5
作者：
PARSONNET, J;HANSEN, S;FRIEDMAN, GD
通讯作者：
FRIEDMAN, GD