Baroreflex sensitivity in men with recent myocardial infarction; impact of age.
Baroreflex sensitivity in men with recent myocardial infarction; impact of age.
复制标题
最近患有心肌梗塞的男性的压力感受反射敏感性；
DOI：
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发表时间：
1994
影响因子：
39.3
通讯作者：
K. Pyörälä
中科院分区：
文献类型：
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作者：
J. Hartikainen;M. Mäntysaari;H. Mussalo;K. Tahvanainen;E. Länsimies;K. Pyörälä
我们研究了年龄对首次心肌梗死（MI）后存活的39例男性患者和15例年龄匹配的对照组的压力反射敏感性（BRS）的影响。心肌梗死组和对照组BRS与年龄呈负相关（r =-0.632，P < 0.0001），与年龄呈负相关（r =-0.706，P < 0.0001）。然而，与健康对照组相比，MI患者的BRS与年龄之间的关系存在显著差异：对照组的BRS显著高于MI患者，BRS-年龄回归斜率显著更陡。因此，MI引起的BRS降低（Δ BRS =年龄特异性预期BRS-测量BRS）与年龄呈负相关（r =-0.66，P < 0.05），即Δ BRS在年轻MI患者中最大。然而，相对BRS（BRS% =测量的BRS除以年龄特异性预期BRS）与年龄无关。心肌梗死组BRS%平均比对照组低37%。MI大小和左心室收缩功能与BRS无关。BRS与心脏舒张功能（左室晚期充盈率r =-0.43，P < 0.05）、运动能力（r = 0.31，P < 0.05）和运动时ST段压低程度（r =-0.40，P < 0.05）相关，但在校正年龄后，所有这些相关性均失去意义。总之，在评估与不同疾病相关的BRS损伤机制时，年龄是一个应考虑的因素。（250字处删节）
We investigated the effect of age on baroreflex sensitivity (BRS) in 39 male patients, who had survived their first myocardial infarction (MI) and in 15 age-matched controls. BRS was inversely related to age in both MI patients (r = -0.632, P < 0.0001) and controls (r = -0.706, P < 0.0001). The relationship between BRS and age, however, was significantly different in MI patients as compared with healthy controls: BRS was markedly higher and the BRS-age regression slope was significantly steeper in controls than in MI patients. As a consequence, the decrease in BRS caused by MI (delta BRS = age-specific expected BRS--measured BRS) was related inversely to age (r = -0.66, P < 0.05) i.e. delta BRS was greatest among young MI patients. However, the relative BRS (BRS% = measured BRS divided by the age-specific expected BRS) did not correlate with age. The average BRS% of MI patients was 37% lower than that of controls. MI size and left ventricular (LV) systolic function did not correlate with BRS. BRS correlated with variables related to cardiac diastolic function (peak late LV filling rate r = -0.43, P < 0.05), exercise capacity (r = 0.31, P < 0.05) and the extent of ST-depression during exercise (r = -0.40, P < 0.05), but all these correlations lost their significance after the adjustment for age. In conclusion, age is a factor that should be taken into consideration when evaluating the mechanisms of BRS impairment associated with different diseases.(ABSTRACT TRUNCATED AT 250 WORDS)