Determinants of serum adiponectin in persons with and without type 1 diabetes
Determinants of serum adiponectin in persons with and without type 1 diabetes
复制标题
DOI：
10.1093/aje/kwm125
复制
发表时间：
2007-09-15
影响因子：
5
通讯作者：
Rewers, Marian
中科院分区：
文献类型：
--
作者：
Maahs, David M.;Ogden, Lorraine G.;Rewers, Marian
低水平的脂联素与冠心病有关，但脂联素在1型糖尿病患者中较高，他们的冠心病发病率增加。在1型糖尿病冠状动脉钙化研究（2000-2002）中，作者研究了1型糖尿病患者脂联素水平升高的潜在决定因素，以及与非糖尿病患者相比是否存在差异。对1,393例患者（性别：48%男性;年龄：38（标准差：9）岁;糖尿病病程：23（标准差：9）年; 54%非糖尿病患者和46% 1型糖尿病患者）进行了血清脂联素测定。脂联素水平的对数转换的决定因素进行了评估，通过多元线性回归分析的相互作用，以确定是否脂联素水平的预测因素不同的糖尿病状态。1型糖尿病患者的脂联素水平高于非糖尿病患者（13.5（标准差：1.0）vs. 8.8（标准差：1.0）μ g/ml; p < 0.0001），校正了年龄、性别、体重指数和肾小球滤过率。最终的回归模型解释了1型糖尿病患者和非糖尿病患者之间脂联素水平差异的67%。解释这种差异的变量包括高密度脂蛋白胆固醇、白蛋白排泄率、纤溶酶原激活物抑制物-1和血红蛋白A1 c水平。1型糖尿病患者脂联素水平高于非糖尿病患者。虽然可以解释一些差异，但需要进一步研究以更好地了解脂联素水平升高与患者结局（包括冠心病）之间的关系。
Low levels of adiponectin have been related to coronary heart disease, but adiponectin is higher in persons with type 1 diabetes who have an increased rate of coronary disease. In the Coronary Artery Calcification in Type 1 Diabetes Study (2000-2002), the authors investigated potential determinants of elevated adiponectin levels in persons with type 1 diabetes and whether a difference exists compared with nondiabetic persons. Serum adiponectin was measured in 1,393 persons (sex: 48% male; age: 38 (standard deviation: 9) years; diabetes duration: 23 (standard deviation: 9) years; 54% nondiabetic and 46% with type 1 diabetes). Determinants of log-transformed adiponectin levels were evaluated by multiple linear regression analysis with interaction terms to determine whether predictors of adiponectin levels differed by diabetes status. Adiponectin levels were higher in type 1 diabetic than nondiabetic persons (13.5 (standard deviation: 1.0) vs. 8.8 (standard deviation: 1.0) mu g/ml; p < 0.0001), adjusting for age, gender, body mass index, and glomerular filtration rate. The final regression model explained 67% of the difference in adiponectin levels between type 1 diabetic and nondiabetic persons. The variables explaining this difference included high density lipoprotein cholesterol, albumin excretion rate, plasminogen activator inhibitor-1, and hemoglobin A1c level. Adiponectin is higher in type 1 diabetic than nondiabetic persons. Although some of the difference can be explained, further study is needed to better understand the relation between elevated adiponectin levels and patient outcomes, including coronary heart disease.