Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia
Chloroquine Remains Effective for Treating Plasmodium vivax Malaria in Pursat Province, Western Cambodia
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DOI：
10.1128/aac.03026-14
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发表时间：
2014-10-01
影响因子：
4.9
通讯作者：
Fairhurst, Rick M.
中科院分区：
文献类型：
--
作者：
Amaratunga, Chanaki;Sreng, Sokunthea;Fairhurst, Rick M.
氯喹（CQ）用于治疗间日疟原虫疟疾，在没有报道CQ耐药性的地区。使用青蒿素（ART）为基础的联合疗法（ACT）治疗CQ敏感的间日疟原虫感染是有效和方便的，但可能会促进同域恶性疟原虫种群ART耐药性的出现和恶化。在这里，我们表明CQ有效地治疗了柬埔寨西部菩萨省的间日疟，在那里抗逆转录病毒疗法耐药的恶性疟原虫高度流行和传播。
Chloroquine (CQ) is used to treat Plasmodium vivax malaria in areas where CQ resistance has not been reported. The use of artemisinin (ART)-based combination therapies (ACTs) to treat CQ-sensitive P. vivax infections is effective and convenient but may promote the emergence and worsening of ART resistance in sympatric Plasmodium falciparum populations. Here, we show that CQ effectively treats P. vivax malaria in Pursat Province, western Cambodia, where ART-resistant P. falciparum is highly prevalent and spreading.