Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones
Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones
复制标题
DOI：
10.1039/b700923b
复制
发表时间：
2007-05-01
期刊：
影响因子：
9.8
通讯作者：
Martin, William H. C.
中科院分区：
文献类型：
--
作者：
Clarke, Paul A.;Santos, Soraia;Martin, William H. C.
在合成中等复杂的有机分子时，将锅、原子和步骤经济(PASE)结合起来，可以显著地使合成路线绿色化。高取代四氢吡喃-4-酮的合成证明了这一点，并通过一系列公认的指标进行了量化，这些指标证明了结合Pase的效率高于传统的合成策略。
The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route. This is demonstrated by the synthesis of highly substituted tetrahydropyran-4-ones and is quantified by a series of recognised metrics, which demonstrate the efficiency of combining PASE over conventional synthetic strategies.