White matter integrity and symptom dimensions of schizophrenia: A diffusion tensor imaging study
White matter integrity and symptom dimensions of schizophrenia: A diffusion tensor imaging study
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DOI：
10.1016/j.schres.2016.11.045
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发表时间：
2017-06-01
影响因子：
4.5
通讯作者：
Kircher, Tilo T. J.
中科院分区：
文献类型：
--
作者：
Bopp, Miriam H. A.;Zoellner, Rebecca;Kircher, Tilo T. J.
大脑区域之间的纤维束连接受损是精神分裂症的一个关键神经病理学发现。精神分裂症的症状维度可以聚类成因子模型。单一综合征与大脑灰质和白质结构的改变有关。我们将单个患者组中精神分裂症的所有核心综合征与白质完整性的变化联系起来。在 26 名男性患者和 26 名健康对照中测量了弥散加权图像 (3T MRI) 和 SAPS/SANS 评分。首先，使用 TBSS 计算各向异性分数 (FA) 的组间差异。其次，精神分裂症的核心症状维度与这些改变的束内的 FA 相关。我们发现组间九个白质束存在差异。幻觉与左钩束和左皮质脊髓束的 FA 呈正相关。自我干扰（被动现象）与右前丘脑辐射中的 FA 呈正相关。阳性形式思维障碍 (FTD) 与右侧扣带回束中的 FA 呈负相关。阴性症状与右前丘脑辐射呈正相关，与右腹侧扣带束呈负相关。我们首次分析了一个精神分裂症患者组的全部精神病理因素。我们可以通过复制幻觉和阴性症状的发现来验证我们关于阳性 FTD 和被动现象的新结果。只有那些在神经发育过程中特定时间最脆弱的大脑回路才会受到特定病理影响（遗传、环境）的影响。这种情况可以解释与特定白质异常相关的特定精神病理学综合征的主导地位。 (C) 2016 Elsevier B.V. 保留所有权利。
Impaired fiber bundle connectivity between brain regions is a key neuropathological finding in schizophrenia. Symptom dimensions in schizophrenia can be clustered into factor models. Single syndromes have been related to grey and white matter brain structure alterations. We associated all core syndromes of schizophrenia in a single patient group with changes in white matter integrity.Diffusion weighted images (3T MRI) and SAPS/SANS scores were measured in 26 male patients and 26 healthy controls. First, group differences in fractional anisotropy (FA) were calculated with TBSS. Second, core symptom dimensions of schizophrenia were correlated with FA within these altered tracts. We found differences between groups in nine white matter tracts.Hallucinations were positively correlated with FA in the left uncinate fasciculus and left corticospinal tract. Ego-disturbances (passivity phenomena) showed a positive correlation with FA in the right anterior thalamic radiation. Positive formal thought disorders (FTD) corresponded negatively with FA in the right cingulum bundle. Negative symptoms were positively associated with the right anterior thalamic radiation and negatively with the right ventral cingulum bundle.For the first time, we analyzed the whole range of psychopathological factors in one schizophrenia patient group. We could validate our novel results for positive FTD and passivity phenomena by replicating findings for hallucinations and negative symptoms. Only those brain circuits which are most vulnerable at a given time during neurodevelopment are affected by a particular pathological impact (genetic, environmental). This scenario could explain the predominance of particular psychopathological syndromes related to specific white matter anomalies. (C) 2016 Elsevier B.V. All rights reserved.